10.5061/DRYAD.QNK98SFBB
Mohajerani, Majid H.
0000-0003-0964-2977
University of Lethbridge
Karimi Abadchi, Javad
0000-0003-4175-7598
University of Lethbridge
Nazari-Ahangarkolaee, Mojtaba
University of Lethbridge
Gattas, Sandra
0000-0003-1608-1469
University of California, Irvine
Bermudez-Contreras, Edgar
0000-0002-4937-1780
University of Lethbridge
McNaughton, Bruce L.
University of Lethbridge
Data from: Spatiotemporal patterns of neocortical activity around
hippocampal sharp-wave ripples
Dryad
dataset
2019
sharp-wave ripples
Natural Sciences and Engineering Research Council
https://ror.org/01h531d29
40352
Alberta Innovates
https://ror.org/00ynafe15
Canadian Institutes of Health Research
https://ror.org/01gavpb45
390930
Defense Advanced Research Projects Agency
https://ror.org/02caytj08
HR0011-18-2-0021
National Science Foundation
https://ror.org/021nxhr62
Alberta Prion Research Institute
43568
2020-05-07T00:00:00Z
2020-05-07T00:00:00Z
en
https://doi.org/10.7554/eLife.51972
465267661 bytes
5
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
A prevalent model is that sharp-wave ripples (SWR) arise ‘spontaneously’
in CA3 and propagate recent memory traces outward to the neocortex to
facilitate memory consolidation there. Using voltage and extracellular
glutamate transient recording over widespread regions of mice dorsal
neocortex in relation to CA1 multiunit activity (MUA) and SWR, we find
that the largest SWR-related modulation occurs in retrosplenial cortex;
however, contrary to the unidirectional hypothesis, neocortical activation
exhibited a continuum of activation timings relative to SWRs, varying from
leading to lagging. Thus, contrary to the model in which SWRs arise
‘spontaneously’ in the hippocampus, neocortical activation often precedes
SWRs and may thus constitute a trigger event in which neocortical
information seeds associative reactivation of hippocampal ‘indices’. This
timing continuum is consistent with a dynamics in which older, more
consolidated memories may in fact initiate the hippocampal-neocortical
dialog, whereas reactivation of newer memories may be initiated
predominantly in the hippocampus.