10.5061/DRYAD.PK75D
Lahti, Leo
University of Helsinki
Salojärvi, Jarkko
University of Helsinki
Salonen, Anne
University of Helsinki
Scheffer, Marten
Wageningen University & Research
de Vos, Willem M.
University of Helsinki
Data from: Tipping elements in the human intestinal ecosystem
Dryad
dataset
2015
Clostridium
Lactobacillus plantarum
Uncultured Clostridiales
Bacteroides fragilis
gut
Clostridium difficile
Prevotella
Alternative stable states
bi-stability
Uncultured Mollicutes
tipping element
critical transitions
Prevotella oralis
Prevotella melaninogenica
Clostridium colinum
Dialister spp.
human
2015-05-19T00:00:00Z
2015-05-19T00:00:00Z
en
https://doi.org/10.1038/ncomms5344
2657809 bytes
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CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
The microbial communities living in the human intestine can have profound
impact on our well-being and health. However, we have limited
understanding of the mechanisms that control this complex ecosystem. Here,
based on a deep phylogenetic analysis of the intestinal microbiota in a
thousand western adults, we identify groups of bacteria that exhibit
robust bistable abundance distributions. These bacteria are either
abundant or nearly absent in most individuals, and exhibit decreased
temporal stability at the intermediate abundance range. The abundances of
these bimodally distributed bacteria vary independently, and their
abundance distributions are not affected by short-term dietary
interventions. However, their contrasting alternative states are
associated with host factors such as ageing and overweight. We propose
that the bistable groups reflect tipping elements of the intestinal
microbiota, whose critical transitions may have profound health
implications and diagnostic potential.
HITChip phylogenetic microarray data matrixProfiling of 130 genus-like
taxa across 1006 western subjects based on the Human Intestinal Tract
(HIT)Chip phylogenetic microarray.HITChip.tabMetadataMetadata for the 1172
samples in the HITChip data matrix including age, sex, geographic region,
DNA extraction information, projectID, probe-level Shannon diversity, BMI
group,subjectID and time point. For units and other details, see the
README file.
Northern Europe
Nordic countries
Eastern Europe
United States
Europe
Ireland
Southern Europe
United Kingdom
Central Europe