10.5061/DRYAD.P5HQBZKPJ
Yeh, Tian-Shin
0000-0002-2266-8920
Harvard University
Yuan, Changzheng
Zhejiang University
Ascherio, Alberto
Harvard University
Rosner, Bernard
Harvard University
Willett, Walter
Harvard University
Blacker, Deborah
Harvard University
Long-term dietary flavonoid intake and subjective cognitive decline in US
men and women
Dryad
dataset
2021
FOS: Health sciences
National Institutes of Health
https://ror.org/01cwqze88
2021-06-17T00:00:00Z
2021-06-17T00:00:00Z
en
1129020 bytes
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CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Objective: To prospectively examine the associations between long-term
dietary flavonoids and subjective cognitive decline (SCD). Methods: We
followed 49,493 women from the Nurses’ Health Study (NHS) (1984-2006) and
27,842 men from the Health Professionals Follow-up Study (HPFS)
(1986-2002). Poisson regression was used to evaluate the associations
between dietary flavonoids (flavonols, flavones, flavanones, flavan-3-ols,
anthocyanins, polymeric flavonoids, and proanthocyanidins) and subsequent
SCD. For the NHS, long-term average dietary intake was calculated from
seven repeated food frequency questionnaires (SFFQs), and SCD was assessed
in 2012 and 2014. For the HPFS, average dietary intake was calculated from
five repeated SFFQs, and SCD assessed in 2008 and 2012. Results: Higher
intake of total flavonoids was associated with lower odds of SCD after
adjusting for age, total energy intake, major non-dietary factors, and
specific dietary factors. Comparing the highest versus the lowest
quintiles of total flavonoid intake, the pooled multivariable-adjusted
odds ratios (ORs) (95% CIs) of 3-unit increments in SCD was 0.81 (0.76,
0.89). In the pooled results, the strongest associations were observed for
flavones (OR=0.62 [0.57, 0.68]), flavanones (0.64 [0.58, 0.68)]), and
anthocyanins (0.76 [0.72, 0.84]) (p trend <0.0001 for all groups).
The dose-response curve was steepest for flavones, followed by
anthocyanins. Many flavonoid-rich foods, such as strawberries, oranges,
grapefruits, citrus juices, apples/pears, celery, peppers, and bananas,
were significantly associated with lower odds of SCD. Conclusion: Our
findings support a benefit of higher flavonoid intakes for maintaining
cognitive function in US men and women.