10.5061/DRYAD.P4Q04
Bäckman, Lars
Karolinska Institute
Waris, Otto
Åbo Akademi University
Johansson, Jarkko
Turku PET Centre
Andersson, Micael
Umeå University
Rinne, Juha O.
Turku PET Centre
Alakurtti, Kati
Turku PET Centre
Soveri, Anna
Åbo Akademi University
Laine, Matti
Åbo Akademi University
Nyberg, Lars
Umeå University
Data from: Increased dopamine release after working-memory updating
training: neurochemical correlates of transfer
Dryad
dataset
2017
2017-08-14T07:46:03Z
2017-08-14T07:46:03Z
en
https://doi.org/10.1038/s41598-017-07577-y
15993054705 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Previous work demonstrates that working-memory (WM) updating training
results in improved performance on a letter-memory criterion task,
transfers to an untrained n-back task, and increases striatal dopamine
(DA) activity during the criterion task. Here, we sought to replicate and
extend these findings by also examining neurochemical correlates of
transfer. Four positron emission tomography (PET) scans using the
radioligand raclopride were performed. Two of these assessed DAD2 binding
(letter memory; n-back) before 5 weeks of updating training, and the same
two scans were performed post training. Key findings were (a) pronounced
training-related behavioral gains in the letter-memory criterion task, (b)
altered striatal DAD2 binding potential after training during
letter-memory performance, suggesting training-induced increases in DA
release, and (c) increased striatal DA activity also during the n-back
transfer task after the intervention, but no concomitant behavioral
transfer. The fact that the training-related DA alterations during the
transfer task were not accompanied by behavioral transfer suggests that
increased DA release may be a necessary, but not sufficient, condition for
behavioral transfer to occur.
Behavioral dataMEMTRAIN2_BehavioralData.xlsxPET Motion
dataCSV-Motion.zipPET DICOM Data part1PET data in DICOM format. Note! All
packages must be downloaded and combined before
unzipping.MEMTRAIN_FINAL_DICOM.zip.001PET DICOM data part 2Download all
packages and combine before unzipping.MEMTRAIN_FINAL_DICOM.zip.002PET
DICOM data part 3Please combine all parts before
unzipping.MEMTRAIN_FINAL_DICOM.zip.003PET DICOM data part
4MEMTRAIN_FINAL_DICOM.zip.004PET DICOM part
5MEMTRAIN_FINAL_DICOM.zip.005PET DICOM part
6MEMTRAIN_FINAL_DICOM.zip.006PET DICOM part
7MEMTRAIN_FINAL_DICOM.zip.007PET DICOM part
8MEMTRAIN_FINAL_DICOM.zip.008PET DICOM part
9MEMTRAIN_FINAL_DICOM.zip.009PET DICOM part
10MEMTRAIN_FINAL_DICOM.zip.010PET DICOM part
11MEMTRAIN_FINAL_DICOM.zip.011PET DICOM part
12MEMTRAIN_FINAL_DICOM.zip.012PET DICOM part
13MEMTRAIN_FINAL_DICOM.zip.013PET DICOM part
14MEMTRAIN_FINAL_DICOM.zip.014PET DICOM part
15MEMTRAIN_FINAL_DICOM.zip.015PET DICOM part
16MEMTRAIN_FINAL_DICOM.zip.016NIFTI-MRI-defaced-MEMTRAIN