10.5061/DRYAD.M67G1
Bukabau, Justine B.
University of Kinshasa
Sumaili, Ernest K.
University of Kinshasa
Cavalier, Etienne
University of Liège
Pottel, Hans
KU Leuven
Kifakiou, Bejos
University of Kinshasa
Nkodila, Aliocha
University of Kinshasa
Makulo, Jean-Robert R
Mokoli, Vieux M.
University of Kinshasa
Zinga, Chantal V.
University of Kinshasa
Longo, Augustin L.
University of Kinshasa
Engole, Yannick M.
University of Kinshasa
Nlandu, Yannick M.
University of Kinshasa
Lepira, François B.
University of Kinshasa
Nseka, Nazaire M.
University of Kinshasa
Krzesinski, Jean-Marie
Delanaye, Pierre
University of Liège
Makulo, Jean Robert R.
University of Kinshasa
Krzesinski, Jean Marie
University of Liège
Data from: Performance of glomerular filtration rate estimation equations
in Congolese healthy adults: inopportunity of ethnic correction
Dryad
dataset
2019
EGFR
creatinine
iohexol
mGFR
ethnic factors
Cystatin C
performance
MDRD
CKD-EPI
2019-02-20T00:00:00Z
en
https://doi.org/10.1371/journal.pone.0193384
33443 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Context and objective: In the estimation of glomerular filtration rate
(GFR), ethnicity is an important determinant. However, all existing
equations have been built solely from Caucasian and Afro-American
populations and they are potentially inaccurate for estimating GFR in
African populations. We therefore evaluated the performance of different
estimated GFR (eGFR) equations in predicting measured GFR (mGFR). Methods:
In a cross-sectional study, 93 healthy adults were randomly selected in
the general population of Kinshasa, Democratic Republic Congo, between
June 2015 and April 2016. We compared mGFR by plasma clearance of iohexol
with eGFR obtained with the Modified Diet in Renal Disease (MDRD) equation
with and without ethnic factor, the Chronic Kidney Disease Epidemiology
(CKD-EPI) serum creatinine (SCr)-based equation, with and without ethnic
factor, the cystatin C-based CKD-EPI equation (CKD-EPI SCys) and with the
combined equation (CKD-EPI SCrCys) with and without ethnic factor. The
performance of the equations was studied by calculating bias, precision
and accuracy within 30% (P30) of mGFR. Results: There were 48 women and 45
men. Their mean age was 45.0±15.7 years and the average body surface area
was 1.68±0.16m2. Mean mGFR was 92.0±17.2 mL/min/1.73m2 (range of 57 to 141
mL/min/1.73m2). Mean eGFRs with the different equations were 105.5±30.1
and 87.2±24.8 mL/min/1.73m² for MDRD with and without ethnic factor,
respectively; 108.8±24.1 and 94.3±20.9 mL/min/1.73m² for CKD-EPI SCr with
and without ethnic factor, respectively, 93.5±18.6 mL/min/1.73m² for
CKD-EPI SCys; 93.5±18.0 and 101±19.6 mL/min/ 1.73m2 for CKD-EPI SCrCys
with and without ethnic factor, respectively. All equations slightly
overestimated mGFR except MDRD without ethnic factor which underestimated
by -3.8±23.0 mL/min /1.73m2. Both CKD-EPI SCr and MDRD with ethnic factors
highly overestimated mGFR with a bias of 17.9±19.2 and 14.5±27.1
mL/min/1.73m2, respectively. There was a trend for better P30 for MDRD and
CKD-EPI SCr without than with the ethnic factor [86.0% versus 79.6% for
MDRD (p = 0.21) and 81.7% versus 73.1% for the CKD-EPI SCr equations (p =
0.057)]. CKD-EPI SCrCys and CKD-EPI SCys were more effective than
creatinine-based equations. Conclusion: In the Congolese healthy
population, MDRD and CKD-EPI equations without ethnic factors had better
performance than the same equations with ethnic factor. The equations
using Cys C (alone or combined with SCr) performed better than the
creatinine-based equations.
Dataset IOHEXOLmGFR: measured glomerular filtration rate, eGFR:estimated
glomerular filtration rate, eGFR MDRD: estimated glomerular filtration
rate by Modification of Diet in Renal Disease with ethnic factor,
eGFRMDRDnef: estimated glomerular filtration rate by Modification of Diet
in Renal Disease without ethnic factor, eGFR CKD-EPIScr:estimated
glomerular filtration rate by Chronic Kidney Disease-Epidemiology
Collaboration equation based on serum creatinine only with ethnic factor,
eGFRCKD-EPI Scrnef: estimated glomerular filtration rate by Chronic Kidney
Disease-Epidemiology Collaboration based on serum creatinine only without
ethnic factor, eGFRSCrCys: estimated glomerular filtration rate by Chronic
Kidney Disease-Epidemiology Collaboration combining creatinine and
cystatine C with ethnic factor, eGFRSCrCysnef: estimated glomerular
filtration rate by Chronic Kidney Disease-Epidemiology Collaboration
combining creatinine and cystatine C without ethnic factor.
Kinshasa
Central Africa