10.5061/DRYAD.M63XSJ3Z8
Dolezal, Adam
0000-0001-6164-1344
University of Illinois System
Gernat, Tim
0000-0002-5977-3900
University of Illinois System
Amy, Geffre
Iowa State University
Harwood, Gyan
0000-0002-0811-7372
University of Illinois System
Jones, Beryl
University of Illinois System
Hamilton, Adam
University of Illinois System
Bonning, Bryony
0000-0002-9956-9613
University of Florida
Toth, Amy
Iowa State University
Robinson, Gene
University of Illinois System
Morselli Gysi, Deisy
0000-0002-5771-8182
Leipzig University
Honey bee virus causes context-dependent changes in host social behavior
Dryad
dataset
2020
United States Department of Agriculture
https://ror.org/01na82s61
2019-67013-29300
National Institute of General Medical Sciences
https://ror.org/04q48ey07
R01GM117467
National Academies Keck Futures Initiative grant *
NAKFI CB4
North American Pollinator Protection Campaign*
Christopher Family Foundation *
National Academies Keck Futures Initiative grant
NAKFI CB4
North American Pollinator Protection Campaign
Christopher Family Foundation
2020-04-06T00:00:00Z
2020-04-06T00:00:00Z
en
https://github.com/gernat/btools
4685552 bytes
4
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Anthropogenic changes create evolutionarily novel environments that
present opportunities for emerging diseases, potentially changing the
balance between host and pathogen. Honey bees provide essential
pollination services, but intensification and globalization of honey bee
management has coincided with increased pathogen pressure, primarily due
to a parasitic mite/virus complex. Here, we investigated how honey bee
individual and social phenotypes are altered by a virus of concern,
Israeli acute paralysis virus (IAPV). Using automated and manual
behavioral monitoring of IAPV-inoculated individuals, we find evidence for
pathogen manipulation of worker behavior by IAPV, and reveal that this
effect depends on social context; i.e., within vs between colony
interactions. Experimental inoculation reduced social contacts between
honey bee colony members, suggesting an adaptive host social immune
response to diminish transmission. Parallel analyses with
dsRNA-immunostimulated bees revealed these behaviors are part of a
generalized social immune defensive response. Conversely, inoculated bees
presented to groups of bees from other colonies experienced reduced
aggression compared dsRNA-immunostimulated bees, facilitating entry into
susceptible colonies. This reduction was associated with a shift in
cuticular hydrocarbons, the chemical signatures used by bees to
discriminate colony members from intruders. These responses were specific
to IAPV infection, suggestive of pathogen manipulation of the host.
Emerging bee pathogens may thus shape host phenotypes to increase
transmission, a strategy especially well-suited to the unnaturally high
colony densities of modern apiculture. These findings demonstrate how
anthropogenic changes could affect arms races between human-managed hosts
and their pathogens to potentially impact global food security.