10.5061/DRYAD.M550M
Mena, Ignacio
Icahn School of Medicine at Mount Sinai
Nelson, Martha I.
National Institutes of Health
Quezada-Monroy, Francisco
Laboratorio Avi-Mex, Mexico City, Mexico
Dutta, Jayeeta
Icahn School of Medicine at Mount Sinai
Cortes-Fernández, Refugio
Icahn School of Medicine at Mount Sinai
Lara-Puente, J. Horacio
Laboratorio Avi-Mex, Mexico City, Mexico
Castro-Peralta, Felipa
National Institutes of Health
Cunha, Luis F.
Icahn School of Medicine at Mount Sinai
Sequeira-Trovão, Nídia
KU Leuven
National Institutes of Health
Lozano-Dubernard, Bernardo
Laboratorio Avi-Mex, Mexico City, Mexico
Rambaut, Andrew
University of Edinburgh
National Institutes of Health
van Bakel, Harm
Icahn School of Medicine at Mount Sinai
García-Sastre, Adolfo
Icahn School of Medicine at Mount Sinai
Data from: Origins of the 2009 H1N1 influenza pandemic in swine in Mexico
Dryad
dataset
2017
Swine
Influenza A virus
2009 pandemic
zoonosis
2017-06-21T00:00:00Z
2017-06-21T00:00:00Z
en
https://doi.org/10.7554/eLife.16777
945860 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Asia is considered an important source of influenza A virus (IAV)
pandemics, owing to large, diverse viral reservoirs in poultry and swine.
However, the zoonotic origins of the 2009 A/H1N1 influenza pandemic virus
(pdmH1N1) remain unclear, due to conflicting evidence from swine and
humans. There is strong evidence that the first human outbreak of pdmH1N1
occurred in Mexico in early 2009. However, no related swine viruses have
been detected in Mexico or any part of the Americas, and to date the most
closely related ancestor viruses were identified in Asian swine. Here, we
use 58 new whole-genome sequences from IAVs collected in Mexican swine to
establish that the swine virus responsible for the 2009 pandemic evolved
in central Mexico. This finding highlights how the 2009 pandemic arose
from a region not considered a pandemic risk, owing to an expansion of IAV
diversity in swine resulting from long-distance live swine trade.
XML files. Datasets for swine influenza phylogenetic analysisDatasets
containing sets of sequences used for the phylogenetic analysis of the
different genomic segments of swine influenzaXML files.zipSupplementary
Data file 1acknowledgement of the authors and research laboratories that
contributed sequence dataData set 1.csvSupplementary Data file
2acknowledgement of the authors and research laboratories that contributed
sequence dataData set 2.csvSupplementary data file 32009 pandemic H1N1
genome sequences used in the analysisData set 3.csvgenebank acc
numbersaccession numbers of the 58 new genomes of swine influenza from
Mexico analyzed in this studyFigure 1 - source data 1source data used in
figure 1 of the manuscriptFigure 2 - figure supplement 1Characteristics of
the 58 swIAVs collected in Mexico for this study.Figure 6 - source data
1Pairwise information on imports of live swine from specific countries is
available from 1996-2012. Data available from the United Nations'
Commodity Trade Statistics Database, http://comtrade.un.org.Figure 7-
source data 1Times to the most recent common ancestor (tMRCA) and
posterior probabilities (>0.01) used in figure 7Figure 7--source
data 1.csv
Mexico
worldwide