10.5061/DRYAD.K98SF7M4G
Roberts, Katherine
University of Exeter
Meaden, Sean
University of Exeter
Sharpe, Stephen
University of Exeter
Doyle, Toby
University of Exeter
Kay, Suzanne
University of Exeter
Bartlett, Lewis
University of Exeter
Paterson, Steve
University of Liverpool
Boots, Mike
University of California, Berkeley
Resource quality determines the evolution of resistance and its genetic basis
Dryad
dataset
2020
Disease Biology
Genomics/Proteomics
Host Parasite Interactions
National Institute of General Medical Sciences
https://ror.org/04q48ey07
R01‐109501,R01‐GM122061‐03
2021-03-05T00:00:00Z
2021-03-05T00:00:00Z
en
https://doi.org/10.1111/mec.15621
175508 bytes
4
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Parasites impose strong selection on their hosts, but the level of any
evolved resistance may be constrained by the availability of resources.
However, studies identifying the genomic basis of such resource-mediated
selection are rare, particularly in non-model organisms. Here, we
investigated the role of nutrition in the evolution of resistance to a DNA
virus (PiGV), and any associated trade-offs in a lepidopteran pest species
(Plodia interpunctella). Through selection experiments and whole genome
re-sequencing we identify genetic markers of resistance that vary between
the nutritional environments during selection. We do not find consistent
evolution of resistance in the presence of virus but rather see
substantial variation among replicate populations. Resistance in a low
nutrition environment is negatively correlated with growth rate,
consistent with an established trade-off between immunity and development,
but this relationship is highly context dependent. Whole genome
resequencing of the host shows that resistance mechanisms are likely to be
highly polygenic and although the underlying genetic architecture may
differ between high and low nutrition environments, similar mechanisms are
commonly used. As a whole, our results emphasise the importance of the
resource environment on influencing the evolution of resistance.