10.5061/DRYAD.HQBZKH1B7
Murray, Gregory P.D.
0000-0001-8197-5173
Liverpool School of Tropical Medicine
Lissenden, Natalie
0000-0002-6578-5537
Liverpool School of Tropical Medicine
Jones, Jeff
Liverpool School of Tropical Medicine
Voloshin, Vitaly
0000-0002-9631-5976
University of Warwick
Toé, K. Hyacinthe
African Training and Research Centre in Administration for Development
Sherrard-Smith, Ellie
0000-0001-8317-7992
Imperial College London
Foster, Geraldine M.
Liverpool School of Tropical Medicine
Churcher, Thomas S.
Imperial College London
Parker, Josephine E.A.
Liverpool School of Tropical Medicine
Towers, Catherine E.
University of Warwick
N’Falé, Sagnon
African Training and Research Centre in Administration for Development
Guelbeogo, Wamdaogo M.
African Training and Research Centre in Administration for Development
Ranson, Hilary
Liverpool School of Tropical Medicine
Towers, David
University of Warwick
McCall, Philip J.
0000-0002-0007-3985
Liverpool School of Tropical Medicine
Data from: Barrier bednets target malaria vectors and expand the range of
usable insecticides
Dryad
dataset
2020
Malaria
Parasitology
MRC
MC_PC_13069
MRC/DFID
MR/M011941/1
Wellcome Trust
https://ror.org/029chgv08
200222/Z/15/Z
2020-09-27T00:00:00Z
2020-01-06T00:00:00Z
en
https://doi.org/10.1038/s41564-019-0607-2
322233 bytes
3
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Transmission of Plasmodium falciparum malaria parasites occurs when
nocturnal Anopheles mosquito vectors feed on human blood. In Africa, where
malaria burden is greatest, bednets treated with pyrethroid insecticide
were highly effective in preventing mosquito bites and reducing
transmission, and essential to achieving unprecedented reductions in
malaria until 2015. Since then, progress has stalled and with insecticidal
bednets losing efficacy against pyrethroid-resistant Anopheles vectors,
methods that restore performance are urgently needed to eliminate any risk
of malaria returning to the levels seen prior to their widespread use
throughout sub-Saharan Africa. Here we show that the primary malaria
vector Anopheles gambiae is targeted and killed by small insecticidal net
barriers positioned above a standard bednet, in a spatial region of high
mosquito activity but zero contact with sleepers, opening the way for
deploying many more insecticides on bednets than currently possible.
Tested against wild pyrethroid-resistant Anopheles gambiae in Burkina
Faso, pyrethroid bednets with organophosphate barriers achieved
significantly higher killing rates than bednets alone. Treated barriers
on untreated bednets were equally effective, without significant loss of
personal protection. Mathematical modelling of transmission dynamics
predicted reductions in clinical malaria incidence with barrier bednets
that exceeded those of ‘next-generation’ nets recommended by WHO against
resistant vectors. Mathematical models of mosquito-barrier interactions
identified alternative barrier designs to increase performance. Barrier
bednets that overcome insecticide resistance are feasible using existing
insecticides and production technology, and early implementation of
affordable vector control tools is a realistic prospect.
BB_Hut_Trial_2017_rotation_plan_Dryad_Sept_2019.xlsx Hut trial data from
Tengrela village, Cascades region, Burkina Faso, 16/07/2017 - 25/08/2017.
Data formatted as simplified version of Kiware et al 2016 ED 2 framework
(https://scfbm.biomedcentral.com/articles/10.1186/s13029-016-0050-1). The
second sheet details the randomised hut trial full latin-square rotation
plan. Any missing values are detailed in the notes section.