10.5061/DRYAD.H752N4Q
Kee, Sara E.
Baylor College of Medicine
Mou, Xiang
Baylor College of Medicine
Zoghbi, Huda Y.
Howard Hughes Medical Institute
Ji, Daoyun
Baylor College of Medicine
Data from: Impaired spatial memory codes in a mouse model of Rett syndrome
Dryad
dataset
2018
2018-07-20T21:26:19Z
2018-07-20T21:26:19Z
en
https://doi.org/10.7554/elife.31451
460562888 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
The Mecp2+/-mouse model recapitulates many phenotypes of patients with
Rett syndrome (RTT), including learning and memory deficits. It is
unknown, however, how the disease state alters memory circuit functions in
vivoin RTT mice. Here we recorded from hippocampal place cells, which are
thought to encode spatial memories, in freely moving RTT mice and
littermate controls. We found that place cells in RTT mice are impaired in
their experience-dependent increase of spatial information. This
impairment is accompanied by an enhanced baseline firing synchrony of
place cells within ripple oscillations during rest, which consequently
occludes the increase in synchrony after a novel experience. Behaviorally,
contextual memory is normal at short but not long time scale in RTT mice.
Our results suggest that hypersynchrony interferes with memory
consolidation and leads to impaired spatial memory codes in RTT mice,
providing a possible circuit mechanism for memory deficits in Rett
Syndrome.
SpikeSourceDataThis is the newer version of the source spike data used in
the analysis, which should replace the old SpikeSourceData. The file can
be opened using the Matlab "load" function. A small modification
is made during the the 2nd revision of the
manuscript.BehavioralSourceData_finalThis is the newer version of the
source behavioral data used in the analysis, which should replace the old
Behavioral Data. The file can be opened using the Matlab "load"
function. A minor modification is made during the the 2nd revision of the
manuscript.