10.5061/DRYAD.F9154
Hofmann, Natalie E.
University of Basel
Karl, Stephan
Papua New Guinea Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
Wampfler, Rahel
Swiss Tropical and Public Health Institute
University of Basel
Kiniboro, Benson
Papua New Guinea Institute of Medical Research
Teliki, Albina
Papua New Guinea Institute of Medical Research
Iga, Jonah
Papua New Guinea Institute of Medical Research
Waltmann, Andreea
University of Melbourne
Walter and Eliza Hall Institute of Medical Research
Betuela, Inoni
Papua New Guinea Institute of Medical Research
Felger, Ingrid
Swiss Tropical and Public Health Institute
University of Basel
Robinson, Leanne J.
University of Melbourne
Mueller, Ivo
Institut Pasteur
University of Melbourne
Walter and Eliza Hall Institute of Medical Research
University of Barcelona
Data from: The complex relationship of exposure to new Plasmodium
infections and incidence of clinical malaria in Papua New Guinea
Dryad
dataset
2017
Plasmodium falciparum
Plasmodium vivax
Plasmodium ovale
Plasmodium malariae
2017-09-01T14:52:58Z
2017-09-01T14:52:58Z
en
https://doi.org/10.7554/elife.23708
1012439 bytes
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CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
The molecular force of blood-stage infection (molFOB) is a quantitative
surrogate metric for malaria transmission at population level and for
exposure at individual level. Relationships between molFOB, parasite
prevalence and clinical incidence were assessed in a
treatment-to-reinfection cohort, where P.vivax (Pv) hypnozoites were
eliminated in half the children by primaquine (PQ). Discounting relapses,
children acquired equal numbers of new P. falciparum (Pf) and Pv
blood-stage infections/year (Pf-molFOB=0-18, Pv-molFOB=0-23) resulting in
comparable spatial and temporal patterns in incidence and prevalence of
infections. Including relapses, Pv-molFOB increased >3-fold
(relative to PQ-treated children) showing greater heterogeneity at
individual (Pv-molFOB=0-36) and village levels. Pf- and Pv-molFOB were
strongly associated with clinical episode risk. Yearly Pf clinical
incidence rate (IR=0.28) was higher than for Pv (IR=0.12) despite lower
Pf-molFOB. These relationships between molFOB, clinical incidence and
parasite prevalence reveal a comparable decline in Pf and Pv transmission
that is normally hidden by the high burden of Pv relapses.
Albinama_eLife_DatabaseData from: The complex relationship of exposure to
new Plasmodium infections and incidence of clinical malaria in Papua New
Guinea.