10.5061/DRYAD.F7M0CFXWZ
Ivimey-Cook, Edward
0000-0003-4910-0443
University of East Anglia
Carlsson, Hanne
University of East Anglia
Duxbury, Elizabeth
University of East Anglia
Edden, Nathan
University of East Anglia
Sales, Kris
University of East Anglia
Maklakov, Alexei
University of East Anglia
Ageing as early-life inertia: disentangling life-history trade-offs along
a lifetime of an individual
Dryad
dataset
2021
Evolution of ageing
Life History Evolution
Senescence
2021-08-20T00:00:00Z
2021-08-20T00:00:00Z
en
740376 bytes
3
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
The theory that ageing evolves because of competitive resource allocation
between the soma and the germline has been challenged by studies showing
that somatic maintenance can be improved without impairing reproduction.
However, it has been suggested that cost-free improvement in somatic
maintenance is possible only under a narrow range of benign conditions.
Here we show that experimental downregulation of insulin/IGF-1 signalling
(IIS) in C. elegans nematodes, a robustly reproducible lifespan and
healthspan-extending treatment, reduces fitness in a complex variable
environment when initiated during development but does not reduce fitness
when initiated in adulthood. Thus, our results show that the costs and
benefits of reduced IIS can be uncoupled when organisms inhabit variable
environments, and, therefore, do not provide support for the resource
allocation theory. Our findings support the theory that the force of
natural selection on gene expression in evolutionarily conserved
signalling pathways that shape life-history traits declines after the
onset of reproduction resulting in organismal senescence.
There are four types of file: qPCR gene expression data Reporduction (long
and wide form) Healthspan Lifespan
The readme file decribes all of the relevant columns.