10.5061/DRYAD.DJ6P6
Fishman, Lila
University of Montana
Kelly, John Kennedy
University of Kansas
Data from: Centromere–associated meiotic drive and female fitness
variation in Mimulus
Dryad
dataset
2015
Selection - Natural
Chromosomal Evolution
Mimulus guttatus
2015-04-15T18:55:57Z
2015-04-15T18:55:57Z
en
https://doi.org/10.1111/evo.12661
102318 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Female meiotic drive, in which chromosomal variants preferentially
segregate to the egg pole during asymmetric female meiosis, is a
theoretically pervasive but still mysterious form of selfish evolution.
Like other selfish genetic elements, driving chromosomes may be maintained
as balanced polymorphisms by pleiotropic or linked fitness costs. A
centromere-associated driver (D) with a ∼58:42 female-specific
transmission advantage occurs at intermediate frequency (32-40%) in the
Iron Mountain population of the yellow monkeyflower, Mimulus guttatus.
Previously determined male fertility costs are sufficient to prevent the
fixation of D, but predict a higher equilibrium frequency. To better
understand the dynamics and effects of D, we developed a new population
genetic model and measured genotype-specific lifetime female fitness in
the wild. In three of four years, and across all years, D imposed
significant recessive seedset costs, most likely due to hitchhiking by
deleterious mutations. With both male and female costs as measured, and
58:42 drive, our model predicts an equilibrium frequency of D (38%) very
close to the observed value. Thus, D represents a rare selfish genetic
element whose local population genetic dynamics have been fully
parameterized, and the observation of equilibrium sets the stage for
investigations of co-evolution with suppressors.
Female fitness data and D genotype for Iron Mountain M. guttatus
(2010-2014)This Excel file includes lifetime female fitness (seedset;
2010-2013), fruit numbers (2010-2013), and flower numbers (2012-2013), as
well as LG11 centromere associated drive genotype (D = driver, determined
by lb5a marker genotype), for individuals sampled from the Iron Mountain,
OR population of Mimulus guttatus. All individuals sampled survived to
produce at least 1 fruit, so these data do not include variation in
survival to reproduction that may be present in the
population.DriveCostsforDryad2015.xlsx
Oregon
Iron Mountain