10.5061/DRYAD.CNP5HQC1W
He, Xingrui
Hangzhou Normal University
Zhuo, Xiao-Tao
Hangzhou Normal University
Gao, Yuan
Guangdong Pharmaceutical University
Bai, Renren
Zhejiang University of Technology
Ye, Xiang-Yang
Hangzhou Normal University
Xie, Tian
Hangzhou Normal University
β-Elemene derivatives produced from SeO2-mediated oxidation reaction
Dryad
dataset
2020
β-elemene
cyclohexyl ring modifications
anti-proliferation
SeO2
Key projects of National Natural Science Foundation of China
81730108
Hangzhou Normal University startup fund
4125C5021920419
National Natural Science Foundation of China
https://ror.org/01h0zpd94
ZR2019BB046
2020-04-03T00:00:00Z
2020-04-03T00:00:00Z
en
3264630 bytes
2
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
We report herein the first access of ß-elemene derivatives through the
SeO2-mediated oxidation reaction. Several new compounds were isolated
through such one-step reaction, and their structures were elucidated using
various 2D-NMR techniques. This method provides easy access to multiple
oxidative ß-elemene derivatives in one single step, and represents the
first cyclohexyl ring modifications of ß-elemene. It’s expected to open up
the opportunity for future derivatization on cyclohexyl ring of ß-elemene.
The new compounds obtained above showed better anti-proliferation
activities on several cancer cell lines than ß-elemene itself.
The 1H NMR, 13C NMR, 1H-1H COSY, 1H-1H NOESY, HMBC, HSQC are recorded in
500 MHz NMR machine. The data were processed in MestReNova software.
There is no any special instruction to obtain the data. Anyone in this
field knows how to record NMR experience and how to interpret data.