10.5061/DRYAD.C3B0260
Panayi, Marios C
University of Oxford
UNSW Sydney
Killcross, Simon
UNSW Sydney
Data from: Functional heterogeneity within the rodent lateral
orbitofrontal cortex dissociates outcome devaluation and reversal learning
deficits
Dryad
dataset
2019
2019-07-26T00:00:00Z
2019-07-26T00:00:00Z
en
https://doi.org/10.7554/elife.37357
32817 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
The orbitofrontal cortex (OFC) is critical for updating reward-directed
behaviours flexibly when outcomes are devalued or when task contingencies
are reversed. Failure to update behaviour in outcome devaluation and
reversal learning procedures are considered canonical deficits following
OFC lesions in non-human primates and rodents. We examined the generality
of these findings in rodents using lesions of the rodent lateral OFC (LO)
in instrumental action-outcome and Pavlovian cue-outcome devaluation
procedures. LO lesions disrupted outcome devaluation in Pavlovian but not
instrumental procedures. Furthermore, although both anterior and posterior
LO lesions disrupted Pavlovian outcome devaluation, only posterior LO
lesions were found to disrupt reversal learning. Posterior but not
anterior LO lesions were also found to disrupt the attribution of
motivational value to Pavlovian cues in sign-tracking. These novel
dissociable task- and subregion-specific effects suggest a way to
reconcile contradictory findings between rodent and non-human primate OFC
research.
PanayiKillcross2018_DatafilesData from all figures and analyses conducted
in Panayi and Killcross (2018, eLife). See 'ReadMe' file for
identification of each file. Data stored as .csv files.