10.5061/DRYAD.BQ18411
Ku, Kuan-Lin
National Tsing Hua University
Wu, Yu-Shan
National Tsing Hua University
Wang, Chi-Yun
Chang Gung Memorial Hospital
Hong, Ding-Wei
National Tsing Hua University
Chen, Zong-Xing
Chang Gung Memorial Hospital
Huang, Ching-An
Chang Gung University
Chu, I-Ming
National Tsing Hua University
Lai, Po-Liang
Chang Gung Memorial Hospital
Data from: Incorporation of surface-modified hydroxyapatite into
poly(methyl methacrylate) to improve biological activity and bone ingrowth
Dryad
dataset
2019
bone cement
Hydroxyapatite
poly(ε-caprolactone)
poly(methyl methacrylate)
Biocompatibility
surface grafting
2019-04-22T17:19:16Z
2019-04-22T17:19:16Z
en
https://doi.org/10.1098/rsos.182060
539277 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Poly(methyl methacrylate) (PMMA) is the most frequently used bone void
filler in orthopedic surgery. However, the interface between the
PMMA-based cement and adjacent bone tissue is typically weak as PMMA bone
cement that is inherently bioinert and not ideal for bone ingrowth. The
present study aims to improve the affinity between the polymer and ceramic
interphases. By surface modifying nano-sized hydroxyapatite (nHAP) with
ethylene glycol and poly(ε-caprolactone) (PCL) sequentially via a two-step
ring opening reaction, affinity was improved between the polymer and
ceramic interphases of PCL-grafted ethylene glycol-HAP (gHAP) in PMMA. Due
to better affinity, the compressive strength of gHAP/PMMA was
significantly enhanced compared to nHAP/PMMA. Further, PMMA with 20 wt.%
gHAP promoted pre-osteoblast cell proliferation in vitro and showed the
best osteogenic activity between the composites tested in vivo. Taken
together, gHAP/PMMA not only improves the interfacial adhesion between the
nanoparticles and cement, but also increases the biological activity and
affinity between the osteoblast cells and PMMA composite cement. These
results show that gHAP and its use in polymer/bioceramic composite have
great potential to improve the functionality of PMMA cement.
Figure 1_TGARaw data for Figure 1Figure 3_Compressive strengthRaw data for
Figure 3Figure 5_CCK-8 assayRaw data for Figure 5Figure 7_ ALP activityRaw
data for Figure 7