10.5061/DRYAD.9594945
Li, Zhong-Min
Technical University Munich
Hernandez-Moreno, David
Helmholtz Zentrum München
Main, Katharina Maria
University of Copenhagen
Skakkebæk, Niels Erik
University of Copenhagen
Kiviranta, Hannu
National Institute for Health and Welfare
Toppari, Jorma
Turku University Hospital
University of Turku
University of Copenhagen
Feldt-Rasmussen, Ulla
University of Copenhagen
Shen, Heqing
Chinese Academy of Sciences
Schramm, Karl-Werner
Technical University Munich
De Angelis, Meri
Helmholtz Zentrum München
Data from: Association of in utero persistent organic pollutant exposure
with placental thyroid hormones
Dryad
dataset
2019
Polychlorinated dibenzo-p-dioxin/furan
Polybrominated diphenyl ether
Persistent organic pollutants
Polychlorinated biphenyl
Organochlorine pesticide
Organotin chemical
Oberschleissheim
2019-06-06T00:00:00Z
2019-06-06T00:00:00Z
en
https://doi.org/10.1210/en.2018-00542
88996 bytes
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CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
In utero exposure to persistent organic pollutants (POPs) can result in
thyroid function disorder, leading to concerns about their impact on fetal
and neonatal development. The present study was performed to investigate
the associations between placental levels of various POPs and thyroid
hormones (THs). In a prospective Danish study initially established for
assessing congenital cryptorchidism, 58 placenta samples were collected
from mothers of boys born with (28) and without (30) cryptorchidism. The
concentrations of polybrominated diphenyl ethers (PBDEs), polychlorinated
biphenyls (PCBs), polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs),
organotin chemicals (OTCs), organochlorine pesticides (OCPs), thyroxine
(T4), 3,3’,5-triiodothyronine (T3), and 3,3’,5’-triiodothyronine (rT3)
were measured. The associations between placental THs and various POPs
were analyzed using multiple linear regression. Five PBDEs, 35 PCBs, 14
PCDD/Fs, 3 OTCs, 25 OCPs, T4, T3, and rT3 were measured. No correlation
between THs and the odds of cryptorchidism was found. Several POPs were
significantly associated with THs: a) T4 was inversely associated with
BDEs 99, 100, ΣPBDE, and 2378-TeCDD, and positively associated with
1234678-HpCDF; b) T3 was positively associated with 2378-TeCDF and
12378-PeCDF; c) rT3 was positively associated with PCB 81, 12378-PeCDF and
234678-HxCDF, and inversely associated with tributyltin (TBT), ΣOTC, and
methoxychlor (MOC). These results revealed that POP exposures were
associated with TH levels in placenta, a possible mechanism for the
impacts of POP exposures on children’s growth and development. This study
provides new insight into the complexity of thyroid-disrupting properties
of POPs. More research is needed to elucidate the biological consequences
of POP exposures.
Supplemental Data_2018_06_04The supplemental material of manuscript
"Association of In Utero Persistent Organic Pollutant Exposure with
Placental Thyroid Hormones". Supplemental method, Supplemental Table
1, Supplemental Table 2, Supplemental Table 3
Germany
Oberschleissheim