10.5061/DRYAD.87C6J
Graffelman, Jan
University of Washington
Weir, Bruce S.
University of Washington
Data from: Multi-allelic exact tests for Hardy-Weinberg equilibrium that
account for gender
Dryad
dataset
2018
Homo Sapiens
X chromosome
indel
2018-01-17T16:40:43Z
2018-01-17T16:40:43Z
en
https://doi.org/10.1111/1755-0998.12748
6838 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Statistical tests for Hardy-Weinberg equilibrium are important elementary
tools in genetic data analysis. X-chromosomal variants have long been
tested by applying autosomal test procedures to females only, and gender
is usually not considered when testing autosomal variants for equilibrium.
Recently, we proposed specific X-chromosomal exact test procedures for
bi-allelic variants that include the hemizygous males, as well as
autosomal tests that consider gender. In this paper we present the
extension of the previous work for variants with multiple alleles. A full
enumeration algorithm is used for the exact calculations of triallelic
variants. For variants with many alternate alleles we use a permutation
test. Some empirical examples with data from the 1000 genomes project are
discussed.
R script analysing variants described in the paperThe file contains R code
that loads the data from the R package HardyWeinberg. Functions are called
that analyse the data and reproduce the tables given in the
paper.ScriptMER.R