10.5061/DRYAD.7V222
Mallarino, Ricardo
Howard Hughes Medical Institute
Henegar, Corneliu
HudsonAlpha Institute for Biotechnology
Mirasierra, Mercedes
Spanish National Research Council
Manceau, Marie
Collège de France
Schradin, Carsten
French National Centre for Scientific Research
Vallejo, Mario
Spanish National Research Council
Beronja, Slobodan
Fred Hutchinson Cancer Research Center
Barsh, Gregory S.
HudsonAlpha Institute for Biotechnology
Hoekstra, Hopi E.
Howard Hughes Medical Institute
Data from: Developmental mechanisms of stripe patterns in rodents
Dryad
dataset
2017
Rhabdomys pumilio
Tamias striatus
2017-09-06T00:00:00Z
2017-09-06T00:00:00Z
en
https://doi.org/10.1038/nature20109
89738227 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Mammalian colour patterns are among the most recognizable characteristics
found in nature and can have a profound impact on fitness. However, little
is known about the mechanisms underlying the formation and subsequent
evolution of these patterns. Here we show that, in the African striped
mouse (Rhabdomys pumilio), periodic dorsal stripes result from underlying
differences in melanocyte maturation, which give rise to spatial variation
in hair colour. We identify the transcription factor ALX3 as a regulator
of this process. In embryonic dorsal skin, patterned expression of Alx3
precedes pigment stripes and acts to directly repress Mitf, a master
regulator of melanocyte differentiation, thereby giving rise to
light-coloured hair. Moreover, Alx3 is upregulated in the light stripes of
chipmunks, which have independently evolved a similar dorsal pattern. Our
results show a previously undescribed mechanism for modulating spatial
variation in hair colour and provide insights into how phenotypic novelty
evolves.
De novo assembly of Rhabdomys pumilio transcriptome and detailed
differential gene expression resultsThis dataset contains a fasta file,
including the de novo assembly of Rhabdomys pumilio transcriptome (built
from RNA-Seq data using the Trinity suite of de novo transcriptome
assembly tools - https://github.com/trinityrnaseq/trinityrnaseq/wiki), as
well as a tab separated text file indicating the gene annotations
corresponding to each assembly contig, obtained by mapping the de novo
assembly to the human reference transcriptome, as described in the
manuscript. A third Excel file contains the detailed results of RNA-Seq
differential gene expression study in skin obtained from three dorsal
regions, as described in the manuscript.Rhabdomys_pumilio.zip
Africa
North America