10.5061/DRYAD.7D7WM37SM
Souza, William Marciel
0000-0002-0025-8293
Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto
Lima, Shirlene Telmos Silva de
Universidade Federal do Ceará
Universidade Federal do Ceará
Cavalcante, John Washington
Universidade Federal do Ceará
Universidade Federal do Ceará
da Silva Candido, Darlan
University of Oxford
University of Oxford
Fumagalli, Marcilio Jorge
Universidade de Ribeirão Preto
Universidade de Ribeirão Preto
Carrera, Jean-Paul
University of Oxford
University of Oxford
Simões Mello, Leda Maria
State University of Ceará
State University of Ceará
de Carvalho Araújo, Fernanda Montenegro
State University of Ceará
State University of Ceará
Cavalcante Ramalho, Izabel Letícia
State University of Ceará
State University of Ceará
de Almeida Barreto, Francisca Kalline
Universidade Federal do Ceará
Universidade Federal do Ceará
de Melo Braga, Deborah Nunes
State University of Ceará
State University of Ceará
Simião, Adriana Rocha
Universidade Federal do Ceará
Universidade Federal do Ceará
Miranda da Silva, Mayara Jane
Instituto Evandro Chagas
Instituto Evandro Chagas
Oliveira, Rhaquel de Morais Alves Barbosa
Universidade Federal do Ceará
Universidade Federal do Ceará
Lima, Clayton Pereira Silva
Instituto Evandro Chagas
Instituto Evandro Chagas
Sousa Lins, Camila de
Faculdade de Medicina do ABC
Faculdade de Medicina do ABC
Barata, Rafael Ribeiro
Instituto Evandro Chagas
Instituto Evandro Chagas
Melo, Marcelo Nunes Pereira
Faculdade de Medicina do ABC
de Souza, Michel Platini Caldas
Instituto Evandro Chagas
Franco, Luciano Monteiro
Faculdade de Medicina do ABC
Távora, Fábio Rocha Fernandes
Faculdade de Medicina do ABC
Queiroz Lemos, Daniele Rocha
Faculdade de Medicina do ABC
Alencar, Carlos Henrique Morais de
Universidade Federal do Ceará
Jesus, Ronaldo de
Universidade Federal de Minas Gerais
Souza Fonseca, Vagner de
Universidade Federal de Minas Gerais
Dutra, Leonardo Hermes
Ministry of Health
Abreu, André Luiz de
Ministry of Health
Araújo, Emerson Luiz Lima
Ministry of Health
Ribas Freitas, André Ricardo
Faculdade São Leopoldo Mandic
Gonçalves Vianez Júnior, João Lídio da Silva
Instituto Evandro Chagas
Pybus, Oliver G
University of Oxford
Moraes Figueiredo, Luiz Tadeu
Universidade de Ribeirão Preto
Faria, Nuno Rodrigues
University of Oxford
Teixeira Nunes, Márcio Roberto
Instituto Evandro Chagas
Góes Cavalcanti, Luciano Pamplona de
Universidade Federal do Ceará
Miyajima, Fabio
Universidade Federal do Ceará
Fatal outcome of chikungunya virus infection in Brazil
Dryad
dataset
2020
São Paulo Research Foundation
https://ror.org/02ddkpn78
2017/13981-0,2018/09383-3,2018/14389-0,2018/00837-1,2019/24251–9
Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico
https://ror.org/007pgtp80
Brazilian National Council for Scientific and Technological Development
302584/2015-3, 408338/2018-0
Wellcome Trust and Royal Society Sir Henry Dale Fellowship
204311/Z/16/Z
2020-08-27T00:00:00Z
2020-08-27T00:00:00Z
en
https://doi.org/10.1093/cid/ciaa1038
89706364 bytes
3
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Abstract Background Chikungunya virus (CHIKV) emerged in the Americas in
2013 and has caused ~2.1 million cases and over 600 deaths. A
retrospective investigation was undertaken to describe clinical,
epidemiological and virus genomic features associated with deaths caused
by CHIKV in Ceará state, northeast Brazil. Methods Sera, cerebrospinal
fluid (CSF) and tissue samples from 100 fatal cases with suspected
arbovirus infection were tested for CHIKV, dengue (DENV) and Zika virus
(ZIKV). Clinical, epidemiological and death reports were obtained for
patients with confirmed CHIKV infection. Logistic regression analysis was
undertaken to identify independent factors associated with risk of death
during CHIKV infection. Phylogenetic analysis was conducted using whole
genomes from a subset of cases. Results 68 fatal cases had CHIKV infection
confirmed by RT-qPCR (52.9%), viral antigen (41.1%), and/or specific-IgM
(63.2%). Co-detection of CHIKV with DENV were found in 22% of fatal cases,
ZIKV in 2.9%, and DENV and ZIKV in 1.5%. A total of 39 CHIKV-deaths
presented with neurological signs and symptoms, and CHIKV-RNA was found in
the CSF of 92.3% of these patients. Fatal outcomes were associated with
irreversible multiple organ dysfunction syndrome. Patients with diabetes
appear to die at a higher frequency during the sub-acute phase. Genetic
analysis showed circulation of two CHIKV-East Central South African (ECSA)
lineages in Ceará and revealed no unique virus genomic mutation associated
with fatal outcome. Conclusion The investigation of the largest
cross-sectional cohort of CHIKV-deaths to date reveals that CHIKV-ECSA
strains can cause death in individuals from both risk and non-risk groups,
including young adults.
Epidemiological data, phylogenetic trees, XMLs, and Ceará CHIKV genome
sequences.