10.5061/DRYAD.6T34B
Greyvenstein, Ockert F. C.
Texas A&M University
Reich, Coralie M.
BioSciences Research Division; Department of Economic Developments,
Jobs, Transport and Resources; 5 Ring Road Bundoora Vic. 3083 Australia
van Marle-Koster, Este
University of Pretoria
Riley, David G.
Texas A&M University
Hayes, Ben J.
La Trobe University
Data from: Polyceraty (multi-horns) in Damara sheep maps to ovine chromosome 2
Dryad
dataset
2016
Ovis aries
Damara sheep
multiple-horns
polycerate
horns
2016-01-22T22:24:16Z
2016-01-22T22:24:16Z
en
https://doi.org/10.1111/age.12411
201917031 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Polyceraty (presence of multiple horns) is rare in modern day ungulates.
Although not found in wild sheep, polyceraty does occur in a small number
of domestic sheep breeds covering a wide geographical region. Damara are
fat-tailed hair sheep, from the south-western region of Africa, which
display polyceraty, with horn number ranging from zero to four. We
conducted a genome-wide association study for horn number with 43 Damara
genotyped with 606 006 SNP markers. The analysis revealed a region with
multiple significant SNPs on ovine chromosome 2, in a location different
from the mutation for polled in sheep on chromosome 10. The causal
mutation for polyceraty was not identified; however, the region associated
with polyceraty spans nine HOXD genes, which are critical in embryonic
development of appendages. Mutations in HOXD genes are implicated in
polydactly phenotypes in mice and humans. There was no evidence for
epistatic interactions contributing to polyceraty. This is the first
report on the genetic mechanisms underlying polyceraty in the
under-studied Damara.
4H_Damara_Phenotypes_BOL-16Aug2015Phenotypes and ID of all animals
included in analysisDamara_OV_FinalReport.txtA zipped folder containing
four .txt files with all the genotypes for the animals used in the
analyses.Concatenating_Genotypes.txt
South Africa