10.5061/DRYAD.6MT70
Zhou, Kali
Guangzhou Eighth People's Hospital
Hu, Fengyu
Guangzhou Eighth People's Hospital
Wang, Charles
University of North Carolina
Xu, Min
Guangzhou Eighth People's Hospital
Lan, Yun
Guangzhou Eighth People's Hospital
Morano, Jamie P.
National Sanitation Foundation International
Lemon, Stanley M.
University of North Carolina
Tucker, Joseph D.
Guangzhou Eighth People's Hospital
Cai, Weiping
Guangzhou Eighth People's Hospital
Data from: Genotypic distribution and hepatic fibrosis among HIV/HCV
co-infected individuals in Southern China: a retrospective cross-sectional
study
Dryad
dataset
2016
Hepatic fibrosis
HIV/HCV co-infection
Human immunodeficiency virus
Hepatitis C
HCV genotype
2016-09-28T00:00:00Z
2016-09-28T00:00:00Z
en
https://doi.org/10.1186/s12879-015-1135-1
198499 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Background: End-stage liver disease and hepatocellular carcinoma due to
hepatitis C virus (HCV) co-infection are increasingly common causes of
death among HIV-infected individuals. However, there are few clinical
investigations of HIV/HCV co-infected individuals from low and
middle-income nations. Here, we compare the epidemiology of HCV-infected
and HIV/HCV co-infected individuals in Southern China and examine hepatic
fibrosis scores in co-infected individuals. Methods: We conducted a
retrospective cross-sectional study of treatment-naïve HIV/HCV co-infected
and HCV mono-infected subjects. Bivariate and multivariate models were
used to examine the association between demographics and HCV genotype.
Among co-infected individuals, we also studied the relationship between
fibrosis scores derived from non-invasive studies and HCV genotype.
Results: Data were collected from 175 HCV-infected individuals, including
89 (51 %) HIV/HCV co-infected individuals. HIV/HCV co-infection was
correlated with intravenous drug use (AOR 46.25, p < 0.001) and not
completing high school (AOR 17.39, p < 0.001) in a multivariate
model. HIV/HCV co-infected individuals were more likely to be infected
with HCV genotype 6a (p < 0.0001) or 3a (p < 0.023), whereas
increased fibrosis (FIB-4 score) was associated with HCV genotype 3a
infection (β 2.18, p < 0.001). Discussion: Our results suggest that
intravenous drug use is driving HIV/HCV co-infection in Southern China.
While additional studies are needed, HCV genotype 6a is more common and
genotype 3a appears to be associated with more severe hepatic fibrosis in
co-infected individuals. Conclusions: Future HIV/HCV co-infection research
in China should focus on at risk populations, HCV testing uptake, and
genotype-specific treatment.
Phylogenetic treePhylogenetic tree analysis of HCV core protein gene
sequences (n = 175). Shown are HCV mono-infected (blue circles) and
HCV/HIV co-infected samples (red triangles)tree--combined-2013-Mar11.JPG