10.5061/DRYAD.6HDR7SQW6
Zhu, Sujuan
0000-0003-4307-8919
Yangzhou University
Shen, Yan
Yangzhou University
Yu, Yongmin
Yangzhou University
Bai, Xuexue
Yangzhou University
Synthesis of antibacterial gold nanoparticles with different particle size
using chlorogenic acid
Dryad
dataset
2019
Chlorogenic acid
gold nanoparticles
Rapid synthesis
Size control
Bacteriostatic
Yangzhou University Cooperation Foundation
204020813
2020-03-04T00:00:00Z
2020-03-04T00:00:00Z
en
https://doi.org/10.1098/rsos.191141
174895 bytes
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CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
This study proposes a strategy for the rapid and simple synthesis of gold
nanoparticles (CGA-AuNPs) with different particle size using trisodium
citrate (TSC) as the first reducing agent and chlorogenic acid (CGA) as
the second reducing agent. And the antibacterial activity of CGA-AuNPs
with different particle size in vitro was verified by measuring the growth
curves of Escherichia coli (E. coli ATCC 25922) and Staphylococcus aureus
(S. aureus ATCC 25923). The CGA-AuNPs obtained by analysis of transmission
electron microscope (TEM) images and UV-visible Spectra were mainly
spherical, and the average diameters were 18.94±1.81nm, 30.42±6.32nm,
37.86±3.80nm, 48.72±6.47nm respectively. High-resolution transmission
electron microscopy (HRTEM) and selected area electron diffraction (SAED)
showed that these nanoparticles were polycrystalline gold structures. Both
of CGA-AuNPs and CGA have excellent antibacterial activity, and CGA-AuNPs
with small particle size has a stronger antibacterial effect than the
larger one. UV-visible absorption spectrum data revealed that the
synthesized CGA-AuNPs without adding other stabilizing agent were well
maintained even after 26 days. This work provides a special idea to
regulate the size of CGA-AuNPs with CGA by chemical synthesis, and the
strong antibacterial activity of these CGA-AuNPs may be applied in the
field of antibacterial in the future.
Data underlying figures 1-3, 5-7 of the associated paper