10.5061/DRYAD.6963PJ3
Andersen, Sandra Breum
University of Oxford
Technical University of Denmark
Ghoul, Melanie
University of Oxford
Marvig, Rasmus Lykke
Rigshospitalet
Lee, Zhuo-Bin
University of Oxford
Molin, Søren
Technical University of Denmark
Johansen, Helle Krogh
Rigshospitalet
University of Copenhagen
Griffin, Ashleigh S.
University of Oxford
Data from: Privatisation rescues essential function following loss of
cooperation
Dryad
dataset
2018
iron metabolism
Social evolution
Holocene
2018-12-18T20:59:26Z
2018-12-18T20:59:26Z
en
https://doi.org/10.7554/eLife.38594
38686 bytes
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CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
A single cheating mutant can lead to the invasion and eventual eradication
of cooperation from a population. Consequently, cheat invasion is often
considered equal to extinction in empirical and theoretical studies of
cooperator-cheat dynamics. But does cheat invasion necessarily equate
extinction in nature? By following the social dynamics of iron metabolism
in Pseudomonas aeruginosa during cystic fibrosis lung infection, we
observed that individuals evolved to replace cooperation with a ‘private’
behaviour. Phenotypic assays showed that cooperative iron acquisition
frequently was upregulated early in infection, which, however, increased
the risk of cheat invasion. With whole-genome sequencing we showed that
if, and only if, cooperative iron acquisition is lost from the population,
a private system was upregulated. The benefit of upregulation depended on
iron availability. These findings highlight the importance of social
dynamics of natural populations and emphasizes the potential impact of
past social interaction on the evolution of private traits.
Pyoverdine productionPyoverdine production of isolates sampled from cystic
fibrosis patients. For each sample is given: the Patient ID, the clone
type, the absolute pyoverdine production as RFU/OD, the sample location,
the length of infection of the clone type and overall in the patient, the
pyoverdine type, the pyoverdine production relative to the first isolate
of the clone type from the patient, and classification as pyoverdine non-,
super-, or producer.Dryad.pyo.prod.xlsx
Denmark