10.5061/DRYAD.64C32M5
Cuomo, Federica
University of Michigan-Ann Arbor
Ferruzzi, Jacopo
Yale University
Agarwal, Pradyumn
University of Michigan-Ann Arbor
Li, Chen
University of Michigan-Ann Arbor
Zhuang, Zhen W.
Yale University
Humphrey, Jay D.
Yale University
Figueroa, C. Alberto
University of Michigan-Ann Arbor
Data from: Sex-dependent differences in central artery hemodynamics in
normal and fibulin-5 deficient mice: implications for ageing
Dryad
dataset
2019
Fluid-Solid Interaction
Pulse Pressure
Pulse Wave Velocity
mechanics
Aorta
Stiffness
2019-01-09T19:59:13Z
2019-01-09T19:59:13Z
en
https://doi.org/10.1098/rspa.2018.0076
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CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Mouse models provide unique opportunities to study vascular disease, but
they demand increased experimental and computational resolution. We
describe a workflow for combining in vivo and in vitro biomechanical data
to build mouse-specific computational models of the central vasculature
including regional variations in biaxial wall stiffness, thickness and
perivascular support. These fluid–solid interaction models are informed by
micro-computed tomography imaging and in vivo ultrasound and pressure
measurements, and include mouse-specific inflow and outflow boundary
conditions. Hence, the model can capture three-dimensional unsteady flows
and pulse wave characteristics. The utility of this
experimental–computational approach is illustrated by comparing central
artery biomechanics in adult wild-type and fibulin-5 deficient mice, a
model of early vascular ageing. Findings are also examined as a function
of sex. Computational results compare well with measurements and data
available in the literature and suggest that pulse wave velocity, a
spatially integrated measure of arterial stiffness, does not reflect well
the presence of regional differences in stiffening, particularly those
manifested in male versus female mice. Modelling results are also useful
for comparing quantities that are difficult to measure or infer
experimentally, including local pulse pressures at the renal arteries and
characteristics of the peripheral vascular bed that may differ with
disease.
Data_Cuomo_et_al_2018
United States