10.5061/DRYAD.601FD
Bahl, Justin
National University of Singapore
Pham, Truc T.
Hill, Nichola J.
Massachusetts Institute of Technology
Hussein, Islam T. M.
Massachusetts Institute of Technology
Ma, Eric J.
Massachusetts Institute of Technology
Easterday, Bernard C.
University of Wisconsin-Madison
Halpin, Rebecca A.
J. Craig Venter Institute
Stockwell, Timothy B.
J. Craig Venter Institute
Wentworth, David E.
J. Craig Venter Institute
Kayali, Ghazi
Krauss, Scott
Schultz-Cherry, Stacey
Webster, Robert G.
Webby, Richard J.
Swartz, Michael D.
Smith, Gavin J. D.
National University of Singapore
Duke University
Runstadler, Jonathan A.
Massachusetts Institute of Technology
Data from: Ecosystem interactions underlie the spread of avian influenza A
viruses with pandemic potential
Dryad
dataset
2017
H9
1979 to 2013
H3
Statistical phylogenetics
Poultry Trade
and H6 Subtype Virus
2017-04-25T00:00:00Z
2017-04-25T00:00:00Z
en
https://doi.org/10.1371/journal.ppat.1005620
6147433 bytes
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CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Despite evidence for avian influenza A virus (AIV) transmission between
wild and domestic ecosystems, the roles of bird migration and poultry
trade in the spread of viruses remain enigmatic. In this study we
integrate ecosystem interactions into a phylogeographic model to assess
the contribution of wild and domestic hosts to AIV distribution and
persistence. Analysis of globally sampled AIV datasets shows frequent
two-way transmission between wild and domestic ecosystems. In general,
viral flow from domestic to wild bird populations was restricted to within
a geographic region. In contrast, spillover from wild to domestic
populations occurred both within and between regions. Wild birds mediated
long-distance dispersal at intercontinental scales whereas viral spread
among poultry populations was a major driver of regional spread. Viral
spread between poultry flocks frequently originated from persistent
lineages circulating in regions of intensive poultry production. Our
analysis of long-term surveillance data demonstrates that meaningful
insights can be inferred from integrating ecosystem into phylogeographic
reconstructions that may be consequential for pandemic preparedness and
livestock protection.
Bahl et al H9 DatasetBahl et al H3 DatasetBahl et al H6
DatasetSuppDataFile2 - Sequence MetadataThis file contains all the
associated metadata used in the ancestral reconstruction of discrete
geographic states.SuppDataFile2 v2.xlsx