10.5061/DRYAD.5T9211B
Ram, Yoav
Hadany, Lilach
Data from: Evolution of stress-induced mutagenesis in the presence of
horizontal gene transfer
Dryad
dataset
2019
Evolution: molecular
Genetics: population
Interactions: coevolution
Theory
Modeling: matrix
Mutation
Genetics: evolutionary
2019-02-14T14:59:17Z
2019-02-14T14:59:17Z
en
https://doi.org/10.1086/703457
21955147 bytes
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CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Stress-induced mutagenesis has been observed in multiple species of
bacteria and yeast. It has been suggested that in asexual populations, a
mutator allele that increases the mutation rate during stress can sweep to
fixation with the beneficial mutations it generates. However, even asexual
microbes can undergo horizontal gene transfer and rare recombination,
which typically interfere with the spread of mutator alleles. Here we
examine the effect of horizontal gene transfer on the evolutionary
advantage of stress-induced mutator alleles. Our results demonstrate that
stress-induced mutator alleles are favored by selection even in the
presence of horizontal gene transfer, and more so when the mutator alleles
also increase the horizontal gene transfer rate. We suggest that when
regulated by stress, mutation and horizontal gene transfer can be
complementary, rather than competing, adaptive strategies, and that
stress-induced mutagenesis has important implications for evolutionary
biology, ecology, and epidemiology, even in the presence of horizontal
gene transfer and rare recombination.
Simulation and analysis dataIncludes results of invasion and adaptation
simulations, and of stability analysis.dryad.zip