10.5061/DRYAD.59645
Yalcindag, Erhan
University of Montpellier
Masaryk University
Rougeron, Virginie
University of Montpellier
Elguero, Eric
University of Montpellier
Arnathau, Céline
University of Montpellier
Durand, Patrick
University of Montpellier
Brisse, Sylvain
Institut Pasteur
Diancourt, Laure
Institut Pasteur
Aubouy, Agnes
Paul Sabatier University
Becquart, Pierre
University of Montpellier
D'Alessandro, Umberto
Institut Pasteur de la Guyane
Fontenille, Didier
University of Montpellier
Gamboa, Dionicia
Cayetano Heredia University
Maestre, Amanda
University of California, Irvine
Ménard, Didier
University of Montpellier
Musset, Lise
Institut Pasteur de la Guyane
Noya, Oscar
Central University of Venezuela
Veron, Vincent
French National Institute for Agricultural Research
Wide, Albina
Central University of Venezuela
Carme, Bernard
University of Montpellier
Legrand, Eric
Institut Pasteur de la Guyane
Chevillon, Christine
University of Montpellier
Ayala, Francisco J.
University of Montpellier
Renaud, François
University of Montpellier
Prugnolle, Franck
University of Montpellier
Data from: Patterns of selection on Plasmodium falciparum erythrocyte
binding antigens after the colonisation of the New World
Dryad
dataset
2014
2014-02-18T14:30:35Z
2014-02-18T14:30:35Z
en
https://doi.org/10.1111/mec.12696
1488682 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Pathogens, which have recently colonized a new host species or new
populations of the same host, are interesting models for understanding how
populations may evolve in response to novel environments. During its
colonization of South America from Africa Plasmodium falciparum, the main
agent of malaria, has been exposed to new conditions in distinctive new
human populations (Amerindian and populations of mixed origins), that
likely exerted new selective pressures on the parasite's genome.
Among the genes that might have experienced strong selective pressures in
response to these environmental changes, the eba genes (erythrocyte
binding antigens genes), which are involved in the invasion of the human
red blood cells, constitute good candidates. In this study, we analyzed,
in South America, the polymorphism of three eba genes (eba-140, eba-175,
eba-181) and compared it to the polymorphism observed in African
populations. The aim was to determine whether these genes faced selective
pressures in South America distinct from what they experienced in Africa.
Patterns of genetic variability of these genes were compared to the
patterns observed at two housekeeping genes (adsl and serca) and 272 SNPs
to separate adaptive effects from demographic effects. We show that,
conversely to Africa, eba-140 seemed to be under stronger diversifying
selection in South America than eba-175. In contrast, eba-181 did not show
any sign of departure from neutrality. These changes in the patterns of
selection on the eba genes could be the consequence of changes in the host
immune response, the host receptor polymorphisms, and / or the ability of
the parasite to silence or express differentially its invasion proteins.
272 SNP dataset_South America_Yalcindag272 SNPs from South American
populationsadsl_sequencesSequences alignment of adsl
geneserca_sequencesSequences alignment of serca
geneeba140_sequencesSequences alignment of eba-140
geneeba175_sequencesSequences alignment of eba-175
geneeba181_sequencesSequences alignment of eba-181 geneSupp table 1
Yalcindag et alSampling details for each population