10.5061/DRYAD.4CP98
Tsagkogeorga, Georgia
University of London
McGowen, Michael R.
Queen Mary University of London
Davies, Kalina T. J.
Queen Mary University of London
Jarman, Simon
Australian Antarctic Division
Polanowski, Andrea
Australian Antarctic Division
Bertelsen, Mads F.
University of London
Rossiter, Stephen J.
Queen Mary University of London
Data from: A phylogenomic analysis of the role and timing of molecular
adaptation in the aquatic transition of cetartiodactyl mammals
Dryad
dataset
2015
Whippomorpha
Cetartiodactyla
Hippopotamidae
Cetacea
2015-09-09T16:25:51Z
2015-09-09T16:25:51Z
en
https://doi.org/10.1098/rsos.150156
51852305 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Recent studies have reported multiple cases of molecular adaptation in
cetaceans related to their aquatic abilities. However, none of these has
included the hippopotamus, precluding an understanding of whether
molecular adaptations in cetaceans occurred before or after they split
from their semi-aquatic sister taxa. Here, we obtained new transcriptomes
from the hippopotamus and humpback whale, and analysed these together with
available data from eight other cetaceans. We identified more than 11 000
orthologous genes and compiled a genome-wide dataset of 6845 coding DNA
sequences among 23 mammals, to our knowledge the largest phylogenomic
dataset to date for cetaceans. We found positive selection in nine genes
on the branch leading to the common ancestor of hippopotamus and whales,
and 461 genes in cetaceans compared to 64 in hippopotamus. Functional
annotation revealed adaptations in diverse processes, including lipid
metabolism, hypoxia, muscle and brain function. By combining these
findings with data on protein–protein interactions, we found evidence
suggesting clustering among gene products relating to nervous and muscular
systems in cetaceans. We found little support for shared ancestral
adaptations in the two taxa; most molecular adaptations in extant
cetaceans occurred after their split with hippopotamids.
Tsagkogeorga_et_al_alignmentsCoding DNA Sequence (CDS) alignments
including 23 mammals.