10.5061/DRYAD.3N901
Eun Sun, Jang
Sook-Hyang, Jeong
Jin-Wook, Kim
Yun Suk, Choi
Philippe, Leissner
Christian, Brechot
Jang, Eun Sun
Seoul National University
Seoul National University Bundang Hospital
Jeong, Sook-Hyang
Seoul National University
Seoul National University Bundang Hospital
Kim, Jin-Wook
Seoul National University
Seoul National University Bundang Hospital
Choi, Yun Suk
Seoul National University
Seoul National University Bundang Hospital
Data from: Diagnostic performance of alpha-fetoprotein, protein induced by
vitamin K absence, osteopontin, Dickkopf-1 and its combinations for
hepatocellular carcinoma
Dryad
dataset
2016
osteopontin
alpha-fetoprotein
dickkopf-1
Hepatocellular carcinoma
PIVKA-II
2016-04-20T15:46:44Z
2016-04-20T15:46:44Z
en
https://doi.org/10.1371/journal.pone.0151069
102713 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Background & Aims: Alpha-fetoprotein (AFP) is the most widely used
serum biomarker for hepatocellular carcinoma (HCC), despite its
limitations. As complementary biomarkers, protein induced by vitamin K
absence (PIVKA-II), osteopontin (OPN), and Dickkopf-1 (DKK-1) have been
proposed. This study aimed to perform a head-to-head comparison of the
diagnostic performance of AFP, PIVKA-II, OPN and DKK-1 as single or in
combination to seek the best biomarker or panel, and to investigate the
clinical factors affecting their performance. Methods: Using 401 stored
plasma samples obtained from 208 HCC patients and 193 liver cirrhosis
control patients, plasma AFP, PIVKA-II, OPN and DKK-1 levels were measured
by ELISA, and receiver operating characteristic curve analyses were
performed for each biomarker and for every combination of two to four
markers. Results: Of the four biomarkers, AFP showed the highest area
under the curve (0.786). The sensitivity and specificity for each single
biomarker was 62% and 90.2% (AFP>20 ng/mL), 51.0% and 91.2%
(PIVKA-II>10 ng/mL), 46.2% and 80.3% (OPN>100 ng/mL), and
50.0% and 80.8% (DKK-1>500 pg/mL), respectively. Among the
combinations of two biomarkers, AFP>20 ng/mL or DKK-1>500
pg/mL showed the best diagnostic performance (sensitivity 78.4%,
specificity 72.5%). Triple or quadruple combination did not improve the
diagnostic performance further. The patient’s age, etiology and tumor
invasiveness of HCC affected the performance of each marker. Conclusions:
AFP was the most useful single biomarker for HCC diagnosis, and the
combined measurement of AFP and DKK-1 could maximize the diagnostic yield.
Clinical decision should be based on the consideration of various factors
affecting the diagnostic performance of each biomarker. Efforts to seek
novel HCC biomarkers should be continued.
HCC_biomarker_160206_data