10.5061/DRYAD.3723P
Testa-Silva, Guilherme
VU University Amsterdam
Erasmus University Medical Center
Netherlands Institute for Neuroscience
Verhoog, Matthijs B.
VU University Amsterdam
Linaro, Daniele
University of Antwerp
de Kock, Christiaan P. J.
VU University Amsterdam
Baayen, Johannes C.
VU University Medical Center
Meredith, Rhiannon M.
VU University Amsterdam
de Zeeuw, Chris I.
Erasmus University Medical Center
Netherlands Institute for Neuroscience
Giugliano, Michele
University of Antwerp
University of Sheffield
Mansvelder, Huibert D.
VU University Amsterdam
Data from: High bandwidth synaptic communication and frequency tracking in
human neocortex
Dryad
dataset
2015
human acute slices
EPSP
Human Cortex
2015-10-23T00:00:00Z
2015-10-23T00:00:00Z
en
https://doi.org/10.1371/journal.pbio.1002007
4224473669 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Neuronal firing, synaptic transmission, and its plasticity form the
building blocks for processing and storage of information in the brain. It
is unknown whether adult human synapses are more efficient in transferring
information between neurons than rodent synapses. To test this, we
recorded from connected pairs of pyramidal neurons in acute brain slices
of adult human and mouse temporal cortex and probed the dynamical
properties of use-dependent plasticity. We found that human synaptic
connections were purely depressing and that they recovered three to four
times more swiftly from depression than synapses in rodent neocortex.
Thereby, during realistic spike trains, the temporal resolution of
synaptic information exchange in human synapses substantially surpasses
that in mice. Using information theory, we calculate that information
transfer between human pyramidal neurons exceeds that of mouse pyramidal
neurons by four to nine times, well into the beta and gamma frequency
range. In addition, we found that human principal cells tracked fine
temporal features, conveyed in received synaptic inputs, at a wider
bandwidth than for rodents. Action potential firing probability was
reliably phase-locked to input transients up to 1,000 cycles/s because of
a steep onset of action potentials in human pyramidal neurons during spike
trains, unlike in rodent neurons. Our data show that, in contrast to the
widely held views of limited information transfer in rodent depressing
synapses, fast recovering synapses of human neurons can actually transfer
substantial amounts of information during spike trains. In addition, human
pyramidal neurons are equipped to encode high synaptic information
content. Thus, adult human cortical microcircuits relay information at a
wider bandwidth than rodent microcircuits.
Index fileList and description of all files and
foldersindex.xlsx30Hz_EPSPsAll EPSPs used as examples on figures 1 and S1
and where all EPSP parameteres have been calculated
from.Code_Fig3_and_SFig2Matlab code used to generate our model based
panels.Figure 1ANeurolucida reconstructed pair of synaptically connected
human pyramidal cells.Poisson_Humanraw traces used in the average trace
displayed in Figure 3B.Poisson_Mouseraw traces used in the average trace
displayed in Figure 3A.Data_Fig5_and_SFig4Raw data used to produce Figure
5 and Figure S4.Data S1Excel sheet with numbers displayed in Figures 1C,
1D, 1E and S1A, S1B, S1C and S1D.Data S2Excel sheet with numbers displayed
in Figure 2.Data S3Excel sheet with numbers displayed in Figures 5 and
S4.Data_Fig4_and_SFig3_HumanRaw data used to produce Figure 4 and Figure
S3 (Human dataset)Data_Fig4_and_SFig3_Mouse_Part1Raw data used to produce
Figure 4 and Figure S3 (Mouse dataset part
1)Data_Fig4_and_SFig3_Mouse_Part2Raw data used to produce Figure 4 and
Figure S3 (Mouse dataset part 2)Data_Fig4_and_SFig3_Mouse_Part3Raw data
used to produce Figure 4 and Figure S3 (Mouse dataset part
3)Data_Fig4_and_SFig3_Mouse_Part4Raw data used to produce Figure 4 and
Figure S3 (Mouse dataset part 4)