10.5061/DRYAD.327V0
Ujvari, Beata
University of Sydney
Pearse, Anne-Maree
Department of Primary Industries, Parks, Water and Environment
Swift, Kate
Department of Primary Industries, Parks, Water and Environment
Hodson, Pamela
Department of Primary Industries, Parks, Water and Environment
Hua, Bobby
Department of Primary Industries, Parks, Water and Environment
Pyecroft, Stephen
Department of Primary Industries, Parks, Water and Environment
University of Adelaide
Taylor, Robyn
Department of Primary Industries, Parks, Water and Environment
Hamede, Rodrigo
University of Tasmania
Jones, Menna
University of Tasmania
Belov, Kathy
University of Wollongong
Madsen, Thomas
University of Wollongong
Belov, Katherine
University of Sydney
Data from: Anthropogenic selection enhances cancer evolution in Tasmanian
devil tumours
Dryad
dataset
2013
Tasmanian devil
Tasmanian devil (Sarcophilus harrisii)
Sarcophilus harrisii
Tetraploidy
Cancer evolution
Tasmanian Devil Facial Tumour Disease
2006-2010
genomic decay
2006-2011
2013-09-19T20:07:10Z
2013-09-19T20:07:10Z
en
https://doi.org/10.1111/eva.12117
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CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
The Tasmanian Devil Facial Tumour Disease (DFTD) provides a unique
opportunity to elucidate the long-term effects of natural and
anthropogenic selection on cancer evolution. Since first observed in 1996,
this transmissible cancer has caused local population declines by
>90%. So far, four chromosomal DFTD variants (strains) have been
described and karyotypic analyses of 253 tumours showed higher levels of
tetraploidy in the oldest strain. We propose that increased ploidy in the
oldest strain may have evolved in response to effects of genomic decay
observed in asexually reproducing organisms. In this study, we focus on
the evolutionary response of DFTD to a disease suppression trial. Tumours
collected from devils subjected to the removal programme showed
accelerated temporal evolution of tetraploidy compared with tumours from
other populations where no increase in tetraploid tumours were observed.
As ploidy significantly reduces tumour growth rate, we suggest that the
disease suppression trial resulted in selection favouring slower growing
tumours mediated by an increased level of tetraploidy. Our study reveals
that DFTD has the capacity to rapidly respond to novel selective regimes
and that disease eradication may result in novel tumour adaptations, which
may further imperil the long-term survival of the world's largest
carnivorous marsupial.
DFTD samples 2006-2011Tumour tissue samples used in the study were
collected between 2006 and 2011 at 12 sites within the DFTD affected areas
of Tasmania.
Tasmania
Australia