10.5061/DRYAD.2S22Q
Labbé, Pierrick
University of Montpellier
Milesi, Pascal
University of Montpellier
Yébakima, André
French National Centre for Scientific Research
Pasteur, Nicole
University of Montpellier
Weill, Mylène
University of Montpellier
Lenormand, Thomas
French National Centre for Scientific Research
Data from: Gene-dosage effects on fitness in recent adaptive duplications:
ace-1 in the mosquito Culex pipiens
Dryad
dataset
2014
trade-offs
Evolutionary genomics
Selection - Natural
Culex pipiens
2014-01-27T15:25:22Z
2014-01-27T15:25:22Z
en
https://doi.org/10.1111/evo.12372
66153 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Gene duplications have long been advocated to contribute to the evolution
of new functions. The role of selection in their early spread is more
controversial. Unless duplications are favored for a direct benefit of
increased expression, they are likely detrimental. In this paper, we
investigated the case of duplications favored because they combine already
functionally divergent alleles. Their gene-dosage/fitness relations are
poorly known, because selection may operate on both overall expression and
duplicates relative dosage. Using the well-documented case of Culex
pipiens resistance to insecticides, we compared strains with various ace-1
allele combinations, including two duplicated alleles carrying both
susceptible and resistant copies. The overall protein activity was nearly
additive, but, surprisingly, fitness correlated better with the relative
proportion of susceptible and resistant copies rather than any absolute
measure of activity. Gene dosage is thus crucial, duplications stabilizing
an ‘heterozygote’ phenotype. It corroborates the view that these were
favored because they fix a permanent heterosis, thereby solving the
irreducible trade-off between resistance and synaptic transmission.
Moreover, we showed that the contrasted successes of the two duplicated
alleles in natural populations depend on genetic changes unrelated to
ace-1, confirming the probable implication of recessive sublethal
mutations linked to structural rearrangements in some duplications.
Activity, preimaginal mortality and resistance dataOriginal data of
activity, preimaginal mortality and resistance of homozygotes for single
copies and two duplicated alleles of the ace-1 gene and their hybrids. For
each variable the indiduals data are provided.DryadDataEvolution.xlsx
Carribbean
France