10.5061/DRYAD.2FQZ612N0
Horne, Malcolm
0000-0001-9427-2100
Florey Institute of Neuroscience and Mental Health
Woodrow, Holly
Florey Institute of Neuroscience and Mental Health
Fernando, Chathurini
Florey Institute of Neuroscience and Mental Health
Kotschet, Katya
St. Vincent's Hospital
A blinded, controlled trial of objective measurement in Parkinson’s disease
Dryad
dataset
2020
Parkinsons disease
Parkinsons Kinetigraph
Michael J. Fox Foundation
https://ror.org/03arq3225
13884
2021-06-21T00:00:00Z
2021-06-21T00:00:00Z
en
https://www.ncbi.nlm.nih.gov/pubmed/33298955
192741 bytes
10
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Medical conditions with effective therapies are usually managed with
objective measurement and therapeutic targets. Parkinson's disease
has effective therapies, but continuous objective measurement has only
recently become available. This blinded, controlled study examined whether
management of Parkinson's disease was improved when clinical
assessment and therapeutic decisions were aided by objective measurement.
The primary endpoint was improvement in the Movement Disorder
Society-United Parkinson's Disease Rating Scale's (MDS-UPDRS)
Total Score. In one arm, objective measurement assisted doctors to alter
therapy over successive visits until objective measurement scores were in
target. Patients in the other arm were conventionally assessed and
therapies were changed until judged optimal. There were 75 subjects in the
objective measurement arm and 79 in the arm with conventional assessment
and treatment. There were statistically significant improvements in the
moderate clinically meaningful range in the MDS-UPDRS Total, III, IV
scales in the arm using objective measurement, but not in the
conventionally treated arm. These findings show that global motor and
non-motor disability is improved when the management of Parkinson's
disease is assisted by objective measurement.
Data was collected in a controlled study. Data includes a) clinical scales
filled in by study particpants and by study co-ordinators; b) reports by
doctors particapting in study; c) data from sensors and written
interpreations of the sensor data.
This information is available in spreadsheets.