10.5061/DRYAD.1G1JWSTSK
Tomoaia-Cotisel, Maria
0000-0002-0995-3006
Babeș-Bolyai University
Mocanu, Aurora
Babeș-Bolyai University
Cadar, Oana
Research Institute for Analytical Instrumentation
Frangopol, Petre
Babeș-Bolyai University
Petean, Ioan
Babeș-Bolyai University
Tomoaia, Gheorghe
Iuliu Hațieganu University of Medicine and Pharmacy
Paltinean, Gertrud-Alexandra
Babeș-Bolyai University
Racz, Csaba Pall
Babeș-Bolyai University
Horovitz, Ossi
Babeș-Bolyai University
Ions release from hydroxyapatite and substituted hydroxyapatites in
different immersion liquids: In vitro experiments and theoretical
modelling study
Dryad
dataset
2020
Mg
Sr
FOS: Chemical sciences
2020-12-28T00:00:00Z
2020-12-28T00:00:00Z
en
57865 bytes
4
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
The multi-substituted hydroxyapatites (ms-HAPs) are currently gaining more
consideration due to their multifunctional properties and biomimetic
structure, owning thus an enhanced biological potential in orthopedic and
dental applications. In this study, nano hydroxyapatite (HAP) substituted
with multiple cations (Sr2+, Mg2+ and Zn2+) for Ca2+ and anion (SiO44-)
for PO43- and OH-, specifically HAPc-5%Sr and HAPc-10%Sr (where HAPc is
HAP-1.5%Mg-0.2%Zn-0.2%Si), both lyophilized noncalcined and lyophilized
calcined, were evaluated for their in vitro ions release. These
nanomaterials were characterized by SEM, FE-SEM and EDX, as well as by AFM
images and by surface-specific areas and porosity. Further, the release of
cations and of phosphate anions were assessed from nano HAP and ms-HAPs,
both in water and in simulated body fluid (SBF), in static and simulated
dynamic conditions, using inductively coupled plasma optical emission
spectrometry (ICP-OES). The release profiles were analyzed and the
influence of experimental conditions was determined for each of the six
nanomaterials and for various periods of time. The pH of the samples
soaked in the immersion liquids was also measured. The ions release
mechanism was theoretically investigated using the Korsmeyer-Peppas model.
The results indicated a mechanism principally based on diffusion and
dissolution, with possible contribution of ion exchange. The surface of
ms-HAP nanoparticles is more susceptible to dissolution into immersion
liquids due to the lattice strain provoked by simultaneous
multi-substitution in HAP structure. According to the findings, it is
rational to suggest that both materials HAPc-5%Sr and HAPc-10%Sr are
bioactive and can be potential candidates in bone tissue regeneration.