10.5061/DRYAD.1C979C0
Pereira, Giovana Rodrigues
Programa de Pós-Graduação em Ciências Pneumológicas da Universidade
Federal do Rio Grande do Sul, Porto Alegre, Brazil
Barbosa, Márcia Silva
Microbiologia, Faculdade Factum, Porto Alegre, Brazil
Dias, Natan José Dutra
Universidade Federal de Ciências da Saúde de Porto Alegre
Almeida, Carlos Podalirio Borges de
Programa de Pós-Graduação em Ciências Pneumológicas da Universidade
Federal do Rio Grande do Sul, Porto Alegre, Brazil
Silva, Denise Rossato
Federal University of Rio Grande do Sul
Data from: Impact of introduction of Xpert MTB/RIF test on tuberculosis
(TB) diagnosis in a city with high TB incidence in Brazil
Dryad
dataset
2018
2018-03-09T06:48:46Z
2018-03-09T06:48:46Z
en
https://doi.org/10.1371/journal.pone.0193988
112931 bytes
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CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Background: Xpert MTB/RIF is increasingly used in many countries as the
initial diagnostic test for tuberculosis (TB). Few studies have evaluated
the effect of Xpert on TB diagnosis under programmatic conditions in
Brazil. The aim of the present study was to evaluate the impact of
introduction of Xpert MTB/RIF on TB diagnosis in a city with high TB
incidence in Brazil. Methods: We included patients evaluated with
conventional diagnostic tests during one year before Xpert introduction
(pre-Xpert group) and patients evaluated using Xpert during one year after
the test introduction (post-Xpert group). Results: 620 patients met the
inclusion criteria (208 in the pre-Xpert group and 412 in the post-Xpert
group) and were included in the analysis. The time until TB diagnosis was
shorter in post-Xpert group (0.7 day, IQR: 0.5–1.0 day) than in pre-Xpert
group (2.0 days, IQR: 2.0–2.0 days) (p<0.0001). Atypical disease
characteristics, such as less weight loss, fever, dyspnea, night sweats,
and hemoptysis; a negative sputum smear; a negative culture, and a chest
X-ray atypical of TB were more common in post-Xpert group than in
pre-Xpert group (p<0.0001 for all). Conclusions: We found that the
implementation of the Xpert MTB/RIF assay, under programmatic conditions,
improve and facilitate TB diagnosis, especially in cases with atypical
disease manifestations. These results are likely to be generalizable to
settings with a similar high TB incidence.
Database_PlosOne_v3