10.5061/DRYAD.08KPRR516
Paukert, Martin
0000-0001-5323-3164
The University of Texas Health Science Center at San Antonio
Ye, Liang
The University of Texas Health Science Center at San Antonio
Orynbayev, Murat
The University of Texas Health Science Center at San Antonio
Zhu, Xiangyu
The University of Texas Health Science Center at San Antonio
Lim, Eunice
The University of Texas Health Science Center at San Antonio
Dereddi, Ram
Heidelberg University
Agarwal, Amit
Heidelberg University
Bergles, Dwight
Johns Hopkins University
Bhat, Manzoor
The University of Texas Health Science Center at San Antonio
Data from: Ethanol abolishes vigilance-dependent astroglia network
activation in mice by inhibiting norepinephrine release
Dryad
dataset
2020
neuroscience, astroglia, astrocyte, vigilance, bahavioral state,
norepinephrine, calcium, locus coeruleus, ethanol
National Institute on Alcohol Abuse and Alcoholism
https://ror.org/02jzrsm59
R01AA025128
National Institute of Mental Health
https://ror.org/04xeg9z08
R01MH113780
National Institute of Mental Health
https://ror.org/04xeg9z08
R01MH083728
Robert J Kleberg Jr and Helen C Kleberg Foundation
https://ror.org/05r5zfp34
Deutsche Forschungsgemeinschaft
https://ror.org/018mejw64
A09N/SFB1158
Chica and Heinz Schaller Foundation
https://ror.org/020m47m04
2020-10-09T00:00:00Z
2020-10-09T00:00:00Z
en
3101526 bytes
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CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
This collection of data sets was obtained during a study of the effect of
acute ethanol intoxication on vigilance-dependent astroglia network
activation in mice. The main findings have been that ethanol inhibits
astroglia activation by inhibiting vigilance-dependent norepinephrine
release. This leads to a failure of activation of alpha1A-adrenergic
receptors on astroglia. Further, this study has revealed that ethanol
inhibition of cerebellar Bergmann glia Ca2+ activation does not account
for ataxic motor behavior, but may rather contribute to cognitive
deficits.
The majority of data were acquired using two-photon Ca2+ imaging in awake
behaving mice on a motorized linear treadmill, or in acute cerebellar
slices. The data have been processed using MATLAB scripts. The study also
includes quantification of motor coordination using the Catwalk XT system.
All data are contained in one Excel file. The data of individual figures
or supplementary figures have been organized into corresponding tabs.
Within each tab the data are organized according to figure sub-panels.
Annotations allow clear association of raw data with individual figure
sub-panels (each dot within data plots is accounted for by its value in
the Excel file). Statistical test results have been included with a
mentioning of the type of test used.