10.5061/DRYAD.0279K
Cook, Peter F.
Emory University
Reichmuth, Colleen
University of California, Santa Cruz
Rouse, Andrew A.
University of California, Santa Cruz
Libby, Laura A.
Dynamic Memory Lab, Center for Neuroscience, University of
California–Davis, Davis, CA 95618, USA.
Dennison, Sophie E.
AnimalScan Advanced Veterinary Imaging, Redwood City, CA 94063, USA.
Carmichael, Owen T.
Pennington Biomedical Research Center
Kruse-Elliott, Kris T.
AnimalScan Advanced Veterinary Imaging, Redwood City, CA 94063, USA.
Bloom, Josh
AnimalScan Advanced Veterinary Imaging, Redwood City, CA 94063, USA.
Singh, Baljeet
Dynamic Memory Lab, Center for Neuroscience, University of
California–Davis, Davis, CA 95618, USA.
Fravel, Vanessa A.
Marine Mammal Center
Barbosa, Lorraine
Marine Mammal Center
Stuppino, Jim J.
AnimalScan Advanced Veterinary Imaging, Redwood City, CA 94063, USA.
Van Bonn, William G.
Shedd Aquarium
Gulland, Frances M. D.
Marine Mammal Center
Ranganath, Charan
Dynamic Memory Lab, Center for Neuroscience, University of
California–Davis, Davis, CA 95618, USA.
Data from: Algal toxin impairs sea lion memory and hippocampal
connectivity, with implications for strandings
Dryad
dataset
2016
Zalophus californianus
Hippocampal connectivity
Memory
Sea lions
Domoic acid
Hippocampus
2016-11-25T00:00:00Z
2016-11-25T00:00:00Z
en
https://doi.org/10.1126/science.aac5675
5496155284 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Domoic acid (DA) is a naturally occurring neurotoxin known to harm marine
animals. DA-producing algal blooms are increasing in size and frequency.
Although chronic exposure is known to produce brain lesions, the influence
of DA toxicosis on behavior in wild animals is unknown. We showed, in a
large sample of wild sea lions, that spatial memory deficits are predicted
by the extent of right dorsal hippocampal lesions related to natural
exposure to DA and that exposure also disrupts hippocampal-thalamic brain
networks. Because sea lions are dynamic foragers that rely on flexible
navigation, impaired spatial memory may affect survival in the wild.
Structural Scans Used For MorphometricsIncluded are T2-weighted structural
scans in nifti format for each of the 41 sea lion subjects in this study.
Scans are oblique, and were obtained perpendicular to the long axis of the
hippocampus. These were the scans used in hippocampal morphometrics, using
Quanta2 software, following tracing criteria detailed in the supplemental
methods.Oblique_T2s.zipFunctional Connectivity MRI Data Part 1Included are
the high-resolution structural scan used for defining thalamic ROIs, left
and right thalamic ROIs in that space, and individual EPI and structural
scans for two sea lion subjects. EPI data represents 15 minutes of
continuous BOLD data under gas anesthesia. All scans are nifti
format.fcMRI1.zipFunctional Connectivity MRI Data Part 2Individual EPI and
structural scans for two sea lion subjects in nifti format. EPI data
represents 15 minutes of continuous BOLD data under gas
anesthesia.fcMRI2.zipFunctional Connectivity MRI Data Part 3Individual EPI
and structural scans for two sea lion subjects in nifti format. EPI data
represents 15 minutes of continuous BOLD data under gas
anesthesia.fcMRI3.zipFunctional Connectivity MRI Data Part 4Individual EPI
and structural scans for two sea lion subjects in nifti format. EPI data
represents 15 minutes of continuous BOLD data under gas
anesthesia.fcMRI4.zipFunctional Connectivity MRI Data Part 5Individual EPI
and structural scans for two sea lion subjects, in nifti format. EPI data
represents 15 minutes of continuous BOLD acquisition under gas
anesthesia.fcMRI5.zipFunctional Connectivity MRI Data Part 6Individual EPI
and structural scans for one sea lion subject, in nifti format. EPI data
represents 15 minutes of continuous BOLD acquisition under gas
anesthesia.fcMRI6.zip