10.4125/pd0006th
Pearson-Long, Morwenna S. M.
Beauseigneur, Alice
Karoyan, Philippe
Szymoniak, Jan
Bertus, Philippe
Titanium-Catalyzed Cyclopropanation
of Boc-Protected Cyanohydrins: A Short Access to Aminocyclopropanecarboxylic
Acid Derivatives
Georg Thieme Verlag, Stuttgart, New York
2010
Chemistry
2010-09-17
en
PrimaryData
10.1055/s-0030-1258260
8458240 Bytes
The preparation of protected 1-aminocyclopropanecarboxylic acid
was performed from readily available and inexpensive starting materials,
using titanium-catalyzed cyclopropanation as the key step. As an
extension of this methodology, a diastereoselective synthesis of
the cis-2-vinyl-substituted analogue
is presented.