10.34865/MB0234FASE6_4AD
Hartwig, Andrea
Andrea
Hartwig
Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
MAK Commission
Permanent Senate Commission for the Investigation of Health Hazards of
Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Aluminium silicate fibres (refractory ceramic fibres, RCF)
MAK Value Documentation, supplement – Translation of the German version from
2019
MAK Value Documentations – Aluminium silicate
fibres (refractory ceramic fibres, RCF)
German Medical Science GMS Publishing House
2021
Aluminiumsilikatfasern
Lunge
Entzündung
Kanzerogenität
Lungentumoren
Mesotheliome
aluminium silicate fibres
lung
inflammation
carcinogenicity
lung tumours
mesotheliomas
Aluminiumsilikatfasern
Lunge
Entzündung
Kanzerogenität
Lungentumoren
Mesotheliome
aluminium silicate fibres
lung
inflammation
carcinogenicity
lung tumours
mesotheliomas
2021
en
Doc080
2509-2383
Creative Commons Attribution 4.0 International License
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated aluminium silicate fibres considering all toxicological endpoints. Aluminium silicate fibres cause mesotheliomas and lung tumours in rats and hamsters. In epidemiological studies, cancer risk was not associated with exposure to aluminium silicate fibres. Tumour formation in animals is a result of chronic inflammation; therefore, aluminium silicate fibres are a candidate for Carcinogen Category 4. However, the re-evaluation showed that a maximum concentration at the workplace (MAK value) cannot be derived and aluminium silicate fibres thus remain classified in Carcinogen Category 2. Aluminium silicate fibres are not taken up via the skin in toxicologically relevant amounts. There are no studies of sensitization.
2509-2383
The MAK Collection for Occupational Health and Safety
MAK Collect Occup Health Saf
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