10.3205/16dgnn21
Dreser, Alice
University Hospital Aachen, Department of Neuropathology, Aachen, Germany
Sechi, Antonio
University Hospital Aachen, Department of Cell Biology, Institute of Biomedical Engineering, Aachen, Germany
Bohlega, Saeed
King Faisal Specialist Hospital and Research Center, Department of Genetics, Riyadh, Saudi Arabia
Troost, Dirk
Academic Medical Centre Amsterdam, Division of Neuropathology, Department of Pathology, Amsterdam, Netherlands
Weis, Joachim
University Hospital Aachen, Department of Neuropathology, Aachen, Germany
Goswami, Anand
University Hospital Aachen, Department of Neuropathology, Aachen, Germany
ALS-linked mutant Sigma receptor-1 leads to defects in protein homeostasis and dysregulation of RNA binding proteins
German Medical Science GMS Publishing House
2016
610 Medical sciences; Medicine
Deutsche Gesellschaft für Neuropathologie und Neuroanatomie|Scandinavian Neuropathological Society
2016-09-14
en
Conference Abstract
urn:nbn:de:0183-16dgnn219
16dgnn21
text/html
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License.
Introduction: Misfolded proteins, which often form intracellular inclusion bodies, are a pathological hallmark of ALS. Disruption of the functional interplay between protein degradation (autophagy) and RNA processing has recently been proposed as an integrated model merging several ALS-associated genes[for full text, please go to the a.m. URL]
Joint-Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN) and the Scandinavian Neuropathological Society (SNS)