10.25560/55142
Cookson, Rosa Ellen
Imperial College London
Chemistry
Studies towards the biomimetic synthesis of resorcylic acid lactones
Imperial College London
2015
Barrett, Anthony
Engineering and Physical Sciences Research Council
2015-09
2017-12-14
Doctor of Philosophy (PhD)
10044/1/55142
Resorcylic acid lactones (RALs) are a biologically important and structurally interesting class of natural products. Recently the Barrett group has developed a novel, biomimetic strategy to access RALs that bypasses many common inefficiencies inherent to more classical synthetic approaches. The focus of this thesis consists of a synthetic study of the RALs radicicol and paecilomycin B that utilised this methodology.