10.25493/X0NS-FP7
Palomero-Gallagher, N.
Zilles, K.
Density measurements of different receptors for CA3 (Hippocampus) [rat, v2.0]
EBRAINS
2020
Neuroscience
Palomero-Gallagher, Nicola
Zilles, Karl
2020-03-28
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
This dataset contains the densities (in fmol/mg protein) of receptors for classical neurotransmitters of CA3 (hippocampus) obtained by means of quantitative _in vitro_ autoradiography. The receptor densities are visualized as _fingerprints_ (**fp**), which provide the mean density and standard deviation for each of the analyzed receptor types, averaged across samples.
Overview of available measurements [ **receptor** \| **_neurotransmitter_** \| _labeling agent_ ]:
**AMPA** \| **_glutamate_** \| _[<sup>3</sup>H]AMPA_
**kainate** \| **_glutamate_** \| _[<sup>3</sup>H]kainate_
**NMDA** \| **_glutamate_** \| _[<sup>3</sup>H]MK-801_
**GABA<sub>A</sub>** \| **_GABA_** \| _[<sup>3</sup>H]muscimol_
**muscarinic M<sub>1</sub>** \| **_acetylcholine_** \| _[<sup>3</sup>H]pirenzepine_
**muscarinic M<sub>2</sub>** \| **_acetylcholine_** \| _[<sup>3</sup>H]oxotremorine-M_
**α<sub>1</sub>** \| **_noradrenalin/norepinephrine_** \| _[<sup>3</sup>H]prazosin_
**α<sub>2</sub>** \| **_noradrenalin/norepinephrine_** \| _[<sup>3</sup>H]UK-14,304_
**5-HT<sub>1A</sub>** \| **_serotonin_** \| _[<sup>3</sup>H]8-OH-DPAT_
**5-HT<sub>2</sub>** \| **_serotonin_** \| _[<sup>3</sup>H]ketanserin_
Information on the used tissue samples and corresponding subjects, as well as analyzed receptors accompanies the provided dataset.
**For methodological details, see:**
Zilles, K. et al. (2002). Quantitative analysis of cyto- and receptorarchitecture of the human brain, pp. 573-602. In: Brain Mapping: The Methods, 2nd edition (A.W. Toga and J.C. Mazziotta, eds.). San Diego, Academic Press.
Palomero-Gallagher N, Zilles K. (2018) Cyto- and receptorarchitectonic mapping of the human brain. In: Handbook of Clinical Neurology 150: 355-387