10.25419/RCSI.10785458
Michelle M. White
Michelle M.
White
Fatma Gargoum
Fatma
Gargoum
Niall Browne
Niall
Browne
Killian Hurley
Killian
Hurley
Royal College of Surgeons in Ireland
Noel G McElvaney
Noel G
McElvaney
Royal College of Surgeons in Ireland
Emer P. Reeves
Emer P.
Reeves
Emer Reeves
Emer
Reeves
Royal College of Surgeons in Ireland
New Research on the Importance of Cystic Fibrosis Transmembrane Conductance Regulator Function for Optimal Neutrophil Activity
<p>Despite tremendous recent advances in our understanding of the molecular and cellular basis of cystic fibrosis (CF), there remains a paradox of why recruited neutrophils fail to eradicate bacterial infections in the airways of individuals with CF. The focus of this chapter is on new research authenticating the CF neutrophil as a key player in disease pathogenesis. Studies specifying intrinsic abnormalities due to a lack of cystic fibrosis transmembrane conductance regulator (CFTR) function, along with reports indicating reprogrammed cell activity secondary to chronic bacterial infection and inflammation, will be discussed.</p>
Medicine
Royal College of Surgeons in Ireland
2022
2022-03-23
2022-03-23
Chapter
4158459 Bytes
CC BY-NC-SA 4.0