10.25402/FSOA.11907195
Mohd Sajjad Ahmad Khan
Fatimah Alshehrei
Saleh Bakheet Al-Ghamdi
Majid Abdullah Bamaga
0000-0002-4417-9845
Abdullah Safar Al-Thubiani
Mohammad Zubair Alam
Graphical Abstract - Virulence and biofilms as promising targets in developing antipathogenic drugs against candidiasis
Graphical abstract: Candida
albicans has remained the main etiological agent of candidiasis, challenges
clinicians with high mortality and morbidity. The emergence of resistance to
antifungal drugs, toxicity and lower efficacy have all contributed to an urgent
need to develop alternative drugs aiming at novel targets in C. albicans.
Targeting the production of virulence factors, which are essential processes
for infectious agents, represents an attractive substitute for the development
of newer anti-infectives. The present review highlights the recent developments
made in the understanding of the pathogenicity of C. albicans. Production of
hydrolytic enzymes, morphogenesis and biofilm formation, along with their
molecular and metabolic regulation in Candida are discussed with regard to the
development of novel anti-pathogenic drugs against candidiasis.
60502 Infectious Agents
60503 Microbial Genetics
60505 Mycology
Future Science Group
2020
2020-02-27
2020-02-27
Figure
214909 Bytes
10.2144/fsoa-2019-0027
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