10.25384/SAGE.C.6384130
Hong-Bo Zeng
Hong-Bo
Zeng
Jun-Di Jiang
Jun-Di
Jiang
Rong Li
Rong
Li
Jian Li
Jian
Li
Wen-Juan Zeng
Wen-Juan
Zeng
Xiong-Kai Li
Xiong-Kai
Li
Bin Hu
Bin
Hu
Fei Zhou
Fei
Zhou
Hai-Ying Yu
Hai-Ying
Yu
Jian-Guo Xie
Jian-Guo
Xie
Zhi-Neng Ning
Zhi-Neng
Ning
Xian Wang
Xian
Wang
The inflammatory cytokine profiles and ocular biometric characteristics of primary angle-closure glaucoma
<div>Objective<p>To investigate the pathogenesis of primary angle-closure disease (PACG) by measuring the anatomical structures of the anterior and posterior segments of the eye and inflammatory markers in the peripheral blood.</p>Methods<p>This case–control study enrolled patients diagnosed with acute PACG (APACG) and chronic PACG (CPACG). It also enrolled control subjects without PACG. The anterior and posterior anatomical features were measured in all study participants. The levels of interleukin (IL)-6, tumour necrosis factor-α and the neutrophil-to-lymphocyte ratio (NLR) in the peripheral blood were measured.</p>Results<p>This study analysed a total of 99 eyes: 34 eyes from 34 patients with APACG, 28 eyes from 28 patients with CPACG and 37 eyes from 37 control patients with senile cataract. The axis length, corneal diameter, anterior chamber depth and anterior chamber volume were significantly smaller in the APACG and CPACG groups compared with the controls. The level of IL-6 in the peripheral blood of patients with PACG was significantly lower than that of the controls. The NLR in the peripheral blood of patients with PACG was significantly greater than that of the controls.</p>Conclusions<p>Changes in the ocular anatomy and some inflammatory markers might be involved in the pathogenesis of PACG.</p></div>
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SAGE Journals
2023
2023-01-13
2023-01-13
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