10.25384/SAGE.C.6346000.V1
Alberto Calvi
Alberto
Calvi
Margareta A Clarke
Margareta A
Clarke
Ferran Prados
Ferran
Prados
Declan Chard
Declan
Chard
Olga Ciccarelli
Olga
Ciccarelli
Manel Alberich
Manel
Alberich
Deborah Pareto
Deborah
Pareto
Marta Rodríguez Barranco
Marta
Rodríguez Barranco
Jaume Sastre-Garriga
Jaume
Sastre-Garriga
Carmen Tur
Carmen
Tur
Alex Rovira
Alex
Rovira
Frederik Barkhof
Frederik
Barkhof
Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis
<div>Background:<p>Magnetic resonance imaging (MRI) markers for chronic active lesions in MS include slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs).</p>Objectives:<p>To identify the relationship between SELs and PRLs in MS, and their association with disability.</p>Methods:<p>61 people with MS (pwMS) followed retrospectively with MRI including baseline susceptibility-weighted imaging, and longitudinal T1 and T2-weighted scans. SELs were computed using deformation field maps; PRLs were visually identified. Mixed-effects models assessed differences in Expanded Disability Status Scale (EDSS) score changes between the group defined by the presence of SELs and or PRLs.</p>Results:<p>The median follow-up time was 3.2 years. At baseline, out of 1492 lesions, 616 were classified as SELs, and 80 as PRLs. 92% of patients had ⩾ 1 SEL, 56% had ⩾ 1 PRL, while both were found in 51%. SELs compared to non-SELs were more likely to also be PRLs (7% vs. 4%, <i>p</i> = 0.027). PRL counts positively correlated with SEL counts (ρ= 0.28, <i>p</i> = 0.03). SEL + PRL + patients had greater increases in EDSS over time (beta = 0.15/year, 95% confidence interval (0.04, 0.27), <i>p</i> = 0.009) than SEL+PRL-patients.</p>Conclusion:<p>SELs are more numerous than PRLs in pwMS. Compared with either SELs or PRLs found in isolation, their joint occurrence was associated with greater clinical progression.</p></div>
Neurology and Neuromuscular Diseases
Aged Health Care
SAGE Journals
2022
2022-12-15
2022-12-15
Collection
10.25384/SAGE.c.6346000
CC BY 4.0