10.25384/SAGE.C.6333899.V1
Emel Rothzerg
Emel
Rothzerg
Wenyu Feng
Wenyu
Feng
Dezhi Song
Dezhi
Song
Hengyuan Li
Hengyuan
Li
Qingjun Wei
Qingjun
Wei
Archa Fox
Archa
Fox
David Wood
David
Wood
Jiake Xu
Jiake
Xu
Yun Liu
Yun
Liu
Single-Cell Transcriptome Analysis Reveals Paraspeckles Expression in Osteosarcoma Tissues
<div><p>Nuclear paraspeckles are subnuclear bodies contracted by nuclear-enriched abundant transcript 1 (NEAT1) long non-coding RNA, localised in the interchromatin space of mammalian cell nuclei. Paraspeckles have been critically involved in tumour progression, metastasis and chemoresistance. To this date, there are limited findings to suggest that paraspeckles, NEAT1 and heterogeneous nuclear ribonucleoproteins (hnRNPs) directly or indirectly play roles in osteosarcoma progression. Herein, we analysed NEAT1, paraspeckle proteins (SFPQ, PSPC1 and NONO) and hnRNP members (HNRNPK, HNRNPM, HNRNPR and HNRNPD) gene expression in 6 osteosarcoma tumour tissues using the single-cell RNA-sequencing method. The normalised data highlighted that the paraspeckles transcripts were highly abundant in osteoblastic OS cells, except NEAT1, which was highly expressed in myeloid cell 1 and 2 subpopulations.</p></div>
Biological Sciences not elsewhere classified
SAGE Journals
2022
2022-12-07
2022-12-07
Collection
10.25384/SAGE.c.6333899
CC BY 4.0