10.25384/SAGE.C.6232855
Zi-Ye Yan
Zi-Ye
Yan
Wan-Qin Hu
Wan-Qin
Hu
Qi-Qun Zong
Qi-Qun
Zong
Guang-Hui Yu
Guang-Hui
Yu
Chun-Xia Zhai
Chun-Xia
Zhai
Lin-Lin Wang
Lin-Lin
Wang
Yu-Hua Wang
Yu-Hua
Wang
Ting-Yu Zhang
Ting-Yu
Zhang
Zhen Li
Zhen
Li
Ying Teng
Ying
Teng
Jing Cai
Jing
Cai
Yang-Fan Chen
Yang-Fan
Chen
Mu Li
Mu
Li
Zhou-Zhou Xu
Zhou-Zhou
Xu
Fa-Ming Pan
Fa-Ming
Pan
Hai-Feng Pan
Hai-Feng
Pan
Hong Su
Hong
Su
Yan-Feng Zou
Yan-Feng
Zou
Associations of RPEL1 and miR-1307 gene polymorphisms with disease susceptibility, glucocorticoid efficacy, anxiety, depression, and health-related quality of life in Chinese systemic lupus erythematosus patients
<div>Objective<p>Our present study intended to examine the associations of RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) with susceptibility, glucocorticoids (GCs) efficacy, anxiety, depression, and health-related quality of life (HRQoL) in Chinese systemic lupus erythematosus (SLE) patients.</p>Methods<p>Initially, 1000 participants (500 SLE cases and 500 controls) were recruited for the case–control study. Then, 429 cases who received GCs were followed through 12 weeks to explore GCs efficacy, depression, anxiety, and HRQoL. We selected the iMLDR technique for genotyping: RPEL1: rs4917385 (G/T) and miR-1307: rs7911488 (A/G).</p>Results<p>The minor G allele of rs7911488 reduced the risk of SLE (<i>p</i> = .024). Four haplotypes consisting of rs4917385 and rs7911488 were associated with SLE susceptibility (<i>p</i> < .025). Both rs4917385 and rs7911488 were associated with anxiety symptoms and physical function (PF) in SLE patients (<i>p</i> < .025). The rs4917385 was associated with depression and its improvement. No statistical significance was found between RPEL1 and miR-1307 gene polymorphisms with GCs efficacy. Meanwhile, additive interaction analysis showed a significant association between RPEL1 and miR-1307 gene polymorphisms with tea consumption in anxiety.</p>Conclusion<p>RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) might be related to SLE susceptibility in Chinese population. Additionally, the two polymorphisms were possibly associated with depression, anxiety, and HRQoL in Chinese SLE population.</p></div>
Aged Health Care
SAGE Journals
2022
2022-10-05
2022-10-05
Collection
CC BY 4.0