10.25384/SAGE.C.5407487
Bo-Wen Zheng
Bo-Wen
Zheng
Wei Huang
Wei
Huang
Fu-Sheng Liu
Fu-Sheng
Liu
Tao-Lan Zhang
Tao-Lan
Zhang
Xiao-Bin Wang
Xiao-Bin
Wang
Jing Li
Jing
Li
Guo-Hua Lv
Guo-Hua
Lv
Yi-Guo Yan
Yi-Guo
Yan
Ming-Xiang Zou
Ming-Xiang
Zou
Clinicopathological and Prognostic Characteristics in Spinal Chondroblastomas: A Pooled Analysis of Individual Patient Data From a Single Institute and 27 Studies
<div>Study Design:<p>Retrospective pooled analysis of individual patient data.</p>Objectives:<p>Spinal chondroblastoma (CB) is a very rare pathology and its clinicopathological and prognostic features remain unclear. Here, we sought to characterize the clinicopathological data of a large spinal CB cohort and determine factors affecting the local recurrence-free survival (LRFS) and overall survival (OS) of patients.</p>Methods:<p>Electronic searches using Medline, Embase, Google Scholar and Wanfang databases were performed to identify eligible studies per predefined criteria. A retrospective review was also conducted to include additional patients at our center.</p>Results:<p>Twenty-seven studies from the literature and 8 patients from our local institute were identified, yielding a total of 61 patients for analysis. Overall, there were no differences in clinicopathological characteristics between the local and literature cohorts, except for absence or presence of spinal canal invasion by tumor on imagings and chicken-wire calcification in tumor tissues. Univariate Kaplan-Meier analysis revealed that previous treatment, preoperative or postoperative neurological deficits, type of tumor resection, secondary aneurysmal bone cyst (ABC), chicken-wire calcification and radiotherapy correlated closely with LRFS, though only type of tumor resection, chicken-wire calcification and radiotherapy were predictive of outcome based on multivariate Cox analysis. Analyzing OS, we found that a history of preoperative treatment, concurrent ABC, chicken-wire calcification, type of tumor resection and adjuvant radiotherapy had a significant association with survival, whereas only type of tumor resection remained statistically significant after adjusting for other covariables.</p>Conclusion:<p>These data may be helpful in prognostic risk stratification and individualized therapy decision making for patients.</p></div>
Neurology and Neuromuscular Diseases
Orthopaedics
Sports Medicine
Surgery
SAGE Journals
2021
2021-04-29
2023-03-01
Collection
CC BY 4.0